Table 3 Meta-analysis of the overall association between ADH1B Arg47His polymorphism and esophageal cancer risk

Total

His vs. Arg

20

0.67 (0.59, 0.76)

<0.00001

<0.00001

87 %

R

His/His vs. Arg/Arg

20

0.40 (0.30, 0.54)

<0.00001

<0.00001

86 %

R

Arg/His vs. Arg/Arg

20

0.52 (0.40, 0.68)

<0.00001

<0.00001

85 %

R

His/His+Arg/His vs. Arg/Arg

22

0.46 (0.36, 0.59)

<0.00001

<0.00001

86 %

R

His/His vs. Arg/His+Arg/Arg

21

0.69 (0.61, 0.77)

<0.00001

<0.00001

69 %

R

Asian

His vs. Arg

18

0.66 (0.57, 0.75)

<0.00001

<0.00001

88 %

R

His/His vs. Arg/Arg

18

0.40 (0.30, 0.54)

<0.00001

<0.00001

87 %

R

Arg/His vs. Arg/Arg

18

0.49 (0.38, 0.65)

<0.00001

<0.00001

86 %

R

His/His+Arg/His vs. Arg/Arg

19

0.44 (0.34, 0.58)

<0.00001

<0.00001

87 %

R

His/His vs. Arg/His+Arg/Arg

19

0.68 (0.61, 0.77)

<0.00001

<0.00001

71 %

R

Non-Asian

His vs. Arg

2

0.93 (0.59, 1.47)

0.75

0.46

0 %

F

His/His vs. Arg/Arg

1

0.82 (0.15, 4.53)

0.82

NA

NA

Arg/His vs. Arg/Arg

2

0.95 (0.57, 1.56)

0.83

0.46

0 %

F

His/His+Arg/His vs. Arg/Arg

3

0.59 (0.23, 1.48)

0.26

0.02

75 %

R

His/His vs. Arg/His+Arg/Arg

1

0.84 (0.15, 4.64)

0.84

NA

NA

China

His vs. Arg

11

0.64 (0.56, 0.73)

<0.00001

<0.00001

78 %

R

His/His vs. Arg/Arg

11

0.37 (0.29, 0.50)

<0.00001

<0.00001

79 %

R

Arg/His vs. Arg/Arg

11

0.47 (0.35, 0.63)

<0.00001

<0.00001

77 %

R

His/His+Arg/His vs. Arg/Arg

11

0.41 (0.31, 0.55)

<0.00001

<0.00001

80 %

R

His/His vs. Arg/His+Arg/Arg

12

0.71 (0.66, 0.76)

<0.00001

0.16

29 %

F

Japan

His vs. Arg

4

0.55 (0.51, 0.60)

<0.00001

0.41

0 %

F

His/His vs. Arg/Arg

4

0.26 (0.18, 0.38)

<0.00001

0.03

66 %

R

Arg/His vs. Arg/Arg

4

0.35 (0.21, 0.59)

<0.00001

0.0008

82 %

R

His/His+Arg/His vs. Arg/Arg

5

0.31 (0.22, 0.44)

<0.00001

0.004

74 %

R

His/His vs. Arg/His+Arg/Arg

4

0.62 (0.56, 0.69)

<0.00001

0.65

0 %

F