Association between alcohol dehydrogenase-2 gene polymorphism and esophageal cancer risk: a meta-analysis

Mao, Ning; Nie, Siyao; Hong, Bin; Li, Chao; Shen, Xueyuan; Xiong, Tao

doi:10.1186/s12957-016-0937-y

World Journal of Surgical Oncology

Table 1 Main characteristics of included studies in this meta-analysis

From: Association between alcohol dehydrogenase-2 gene polymorphism and esophageal cancer risk: a meta-analysis

First author	Year	Country	Ethnicity	Mean age		Sample size		Source of		Genotyping methods
				Cases	Controls	Cases	Controls	Cases	Controls	Genotyping methods
Yokoyama A	2001	Japan	Asian	56 ± 7	53 ± 8	112	526	ESCC	HB	PCR-RFLP
Boonyaphiphat P	2002	Thailand	Asian	64.0 ± 9.7	64.5 ± 12.3	202	261	ESCC	HB	APLP
Chao YC	2003	China (Taiwan)	Asian	64.6 ± 12.3	53.0 ± 18.8	88	105	EC	HB	PCR-RFLP
Yokoyama T	2003	Japan	Asian	61.7 ± 7.9	58.9 ± 7.1	233	610	ESCC	PB	PCR-RFLP
Chen HG	2005	China	Asian	58.06 (35–80)	58.53 (35–82)	137	137	EC	PB	PCR
Yang CX	2005	Japan	Asian	61.4 ± 0.6	61.4 ± 0.4	165	495	ESCC/EAC	HB	PCR-CTPP
Hashibe M	2006	Mixed	Caucasian	56.7 ± 2.1	58.9 ± 3.4	167	887	ESCC	PB	TaqMan
Yang SJ	2007	China	Asian	58.3 ± 8.3	52.8 ± 13.2	191	198	EC	PB	PCR-CTPP
Guo YM	2008	China	Asian	60.2 ± 8.9	59.7 ± 9.7	80	480	ESCC	PB	PCR-RFLP
Lee CH	2008	China (Taiwan)	Asian	60.2 ± 3.8	61.3 ± 3.9	406	656	ESCC	HB	PCR-RFLP
Akbai	2009	Iran	Asian	63.6 (25–89)	55.2 (24–90)	746	1373	ESCC	PB	Sequenom
Cui R	2009	Japan	Asian	64.2 ± 8.7	59.7 ± 16.2	1070	2836	ESCC	PB	BeadChip
Ding JH	2010	China	Asian	68.2 ± 5.6	69.8 ± 7.3	221	191	EC	PB	PCR-DHPLC
Tanaka F	2010	Japan	Asian	67.2 ± 7.3	66.5 ± 7.2	742	820	OSCC	PB	BRLMM
Iqbal B	2011	Kashmir	Asian	NA	NA	50	50	EC	PB	Sequencing
Wang YL	2011	China	Asian	57.2 ± 9.4	56.1 ± 7.3	81	162	EC	PB	PCR-CTPP
Gu HY	2012	China	Asian	62.5 ± 6.2	63.8 ± 7.1	380	380	ESCC	HB	MALDI-ToF-MS
Dura P	2013	Dutch	Caucasian	65.0 ± 10.9	64.9 ± 11.1	351	430	ESCC/EAC	PB	TaqMan
Gao Y	2013	China	Asian	NA	NA	2139	2273	ESCC	PB	TaqMan
Wu M	2013	China	Asian	63.7 ± 9.4	63.7 ± 10.3	846	1079	EC	PB	Sequencing
Hou AM	2014	China	Asian	56.5 ± 5.5	58.7 ± 6.3	110	110	ESCC/EAC	PB	PCR-RFLP
Ye B	2014	China	Asian	58.7 ± 6.4	59.9 ± 7.2	1001	1391	ESCC	HB	PCR-RFLP
Babiker H	2015	Sudan	Africa	56.41	47.87	134	233	ESCC/EAC	PB	PCR-RFLP

NA not available, ESCC esophageal squamous cell carcinoma, EAC esophageal adenocarcinoma, OSCC oesophageal squamous cell carcinoma, HB hospital-based, PB population-based, NP normal healthy population, APLP amplified product length polymorphism method, PCR-CTPP polymerase chain reaction with the confronting two-pair primer, PCR-DHPLC polymerase chain reaction and denaturing high-performance liquid chromatography, BRLMM Bayesian robust linear model with Mahalanobis algorithm, MALDI-ToF-MS matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry

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ISSN: 1477-7819

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