Table 1 Association of miR-452 expression with clinicopathological factors in osteosarcoma
Clinicopathological features | Number of cases | miR-452 expression | P | |
|---|---|---|---|---|
High | Low | |||
n (%) | n (%) | |||
Age | ||||
<20 years | 70 | 33 (47.1 %) | 37 (52.9 %) | 0.352 |
≥20 years | 25 | 15 (60.0 %) | 10 (40.0 %) | |
Gender | ||||
Male | 68 | 35 (51.5 %) | 33 (48.5 %) | 0.823 |
Female | 27 | 13 (48.1 %) | 14 (51.9 %) | |
Tumor size | ||||
>8 cm | 39 | 14 (35.9 %) | 25 (64.1 %) | 0.012 |
≤8 cm | 56 | 34 (60.7 %) | 22 (39.3 %) | |
Anatomic location | ||||
Tibia/femur | 66 | 31 (47.0 %) | 35 (53.0 %) | 0.374 |
Elsewhere | 29 | 17 (58.6 %) | 12 (41.4 %) | |
Tumor grade | ||||
Low | 31 | 22 (71.0 %) | 9 (29.0 %) | 0.008 |
High | 64 | 26 (40.6 %) | 38 (59.4 %) | |
Histological type | ||||
Osteoblastic | 33 | 19 (57.6 %) | 14 (42.4 %) | 0.830 |
Fibroblastic | 21 | 10 (47.6 %) | 11 (52.4 %) | |
Chondroblastic | 14 | 6 (42.9 %) | 8 (57.1 %) | |
Telangiectatic | 15 | 8 (53.3 %) | 7 (46.7 %) | |
Others | 12 | 5 (41.7 %) | 7 (58.3 %) | |
Enneking stage | ||||
I | 24 | 20 (83.3 %) | 4 (16.7 %) | <0.001 |
II | 48 | 23 (47.9 %) | 25 (52.1 %) | |
III | 23 | 5 (21.7 %) | 18 (78.3 %) | |
Distant metastasis | ||||
Absent | 72 | 43 (59.7 %) | 29 (40.3 %) | 0.001 |
Present | 23 | 5 (21.7 %) | 18 (78.3 %) | |