Table 1 Clinicopathological characteristics of stage I–III undifferentiated gastric adenocarcinoma in terms of histology type
Parameters | MC (n = 54) | SRCC (n = 545) | PDC (n = 871) | P value |
|---|---|---|---|---|
Age (years), mean ± SD | 64.2 ± 10.7 | 58.4 ± 13.4 | 62.5 ± 13.8 | <0.0001 |
Median | 66.0 | 59.0 | 65.0 | |
Sex | <0.001 | |||
Male | 31 (57.4) | 269 (49.4) | 522 (59.9) | |
Female | 23 (42.6) | 276 (50.6) | 349 (40.1) | |
Tumor size (cm), mean ± SD | 6.4 ± 3.9 | 4.3 ± 3.4 | 5.1 ± 3.2 | <0.0001 |
Median | 5.5 | 3.5 | 4.5 | |
Type of gastrectomy | 0.006 | |||
Total | 16 (29.6) | 133 (24.4) | 282 (32.4) | |
Subtotal | 38 (70.4) | 412 (75.6) | 589 (67.6) | |
Extent of LN dissection | 0.773 | |||
<D2 | 21 (38.9) | 187 (34.3) | 308 (35.4) | |
≥D2 | 33 (61.1) | 358 (65.7) | 563 (64.6) | |
No. of LN retrieval, mean ± SD | 27.3 ± 15.8 | 28.1 ± 15.3 | 27.7 ± 14.7 | 0.856 |
Median | 23.0 | 25.0 | 25.0 | |
T status | <0.0001 | |||
T1 | 2 (3.7) | 163 (29.9) | 101 (11.6) | |
T2 | 9 (16.7) | 56 (10.3) | 74 (8.5) | |
T3 | 3 (5.6) | 19 (3.5) | 24 (2.8) | |
T4 | 40 (74.1) | 307 (56.3) | 672 (77.2) | |
LN status | ||||
N0 | 13 (24.1) | 251 (46.1) | 244 (28.0) | <0.0001 |
N1 | 11 (20.4) | 59 (10.8) | 119 (13.7) | |
N2 | 12 (22.2) | 66 (12.1) | 56 (17.9) | |
N3 | 18 (33.3) | 169 (31.0) | 352 (40.4) | |
Stage | <0.0001 | |||
I | 5 (9.3) | 190 (34.9) | 120 (13.8) | |
II | 10 (18.5) | 94 (17.2) | 170 (19.5) | |
III | 39 (72.2) | 261 (47.9) | 581 (66.7) | |
Positive margins (R1 resection) | 8 (14.8) | 59 (10.8) | 95 (10.9) | 0.662 |
Lymphatic invasiona | <0.0001 | |||
No | 21 (39.6) | 288 (53.4) | 315 (36.7) | |
Yes | 32 (60.4) | 251 (46.6) | 544 (63.3) | |
Vascular invasiona | 0.005 | |||
No | 44 (83.0) | 479 (89.2) | 710 (82.9) | |
Yes | 9 (17.0) | 58 (10.8) | 146 (17.1) | |
Perineural invasiona | 0.001 | |||
No | 27 (51.9) | 294 (54.9) | 380 (44.3) | |
Yes | 25 (48.1) | 242 (45.1) | 477 (55.7) | |
Complicationsb | 12 (22.2) | 61 (11.2) | 136 (15.6) | 0.016 |
Surgery-related | 10 (18.5) | 49 (9.0) | 99 (11.4) | 0.064 |
Leakage | 5 (9.3) | 26 (4.8) | 46 (5.3) | |
Intra-abdominal abscess | 4 (7.4) | 18 (3.3) | 38 (4.4) | |
Wound infection | 1 (1.9) | 5 (0.9) | 22 (2.5) | |
Bleeding | 1 (1.9) | 9 (1.7) | 11 (1.3) | |
Delayed gastric emptying | 0 | 1(0.2) | 6 (0.7) | |
Others | 1 (1.9) | 3 (0.6) | 4 (0.5) | |
Surgery unrelated | 3 (5.6) | 19 (3.5) | 59 (6.8) | 0.031 |
Pneumonia | 1 (1.9) | 2 (0.4) | 15 (1.7) | |
Cardiovascular event | 1 (1.9) | 5 (0.9) | 7 (0.8) | |
Sepsis | 0 | 2 (0.4) | 8 (0.9) | |
Paralytic ileus | 0 | 2 (0.4) | 5 (0.6) | |
Atelectasis | 0 | 0 | 6 (0.7) | |
Others | 4 (7.4) | 21 (3.9) | 45 (5.2) | |
Hospital mortality | 4 (7.4) | 14 (2.6) | 33 (3.8) | 0.130 |
Chemotherapyc | 38 (84.4) | 285 (81.7) | 553 (75.6) | 0.047 |