Table 1 SphK/S1P/S1PR1 axis in cancer
From: The SphKs/S1P/S1PR1 axis in immunity and cancer: more ore to be mined
Which type | Main cancer/bad outcomes | Mechanism/causes | References |
|---|---|---|---|
Sphk1↑ | Breast cancer | Hemangiogenesis | |
Glioma | Lymphangiogenesis | ||
B17 melanoma malignance | IL-17↑ → IL-6–Stat3↑ → stat3↑ | ||
MB49 bladder malignance | |||
SphK2 ↓ | Colitis-associated tumorigenesis | SphK1↑ | [80] |
SphK1/S1P/S1PR1 axis↑ | |||
NF-κB/STAT3 ↑ | |||
S1P↑ | Colon cancer | S1P lyase↓ → p53-, p38-dependent pathways ↑ | |
Melanoma | SGPL1 gene ↑ → S1P lyase disruption ↑ → Bcl-2, Bcl-xL dependent pathways | ||
Resistance to chemotherapy | |||
Stat3↑ | Melanoma | RelA acetylation → NF-κB↑ | |
Myeloid cell-dependent tumor | BRAF–MAPK↑ | ||
A2058 tumor cells malignance | VEGF/bFGF → tube formation |