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Table 3 Associations between the response of induction chemotherapy and clinicopathologic parameters in 162 smoking patients with locally advanced stage IV head and neck squamous cell carcinoma receiving induction chemotherapy with TPF

From: Betel nut chewing history is an independent prognosticator for smoking patients with locally advanced stage IV head and neck squamous cell carcinoma receiving induction chemotherapy with docetaxel, cisplatin, and fluorouracil

Parameters   Response to induction chemotherapy
   CR/PR SD/PD P value
Age <53 years old 47 34 0.42
  53 years old 52 29  
Sex Male 96 60 0.68
  Female 3 3  
Clinical 7th AJCC stage IVA 47 33 0.54
  IVB 52 30  
Clinical T classification T1~T4a 55 37 0.69
  T4b 44 26  
Clinical N classification N0/1 35 13 0.045*
  N2/3 64 50  
Primary tumor site Oral cavity 35 27 0.34
  Others 64 36  
Primary tumor site Oropharynx 40 20 0.27
  Others 59 43  
Primary tumor site Larynx/hypopharynx 23 13 0.70
  Others 76 50  
Alcohol Absent 10 6 0.90
  Present 89 57  
Betel nut chewing Absent 24 7 0.038*
  Present 75 56  
  1. TPF docetaxel, cisplatin, and fluorouracil; CR complete response; PR partial response; SD stable disease; PD progression disease
  2. *Statistically significant. х 2 test, Fisher’s exact test, or t test was used for statistically analyzed