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Table 2 Associations between betel nut chewing and clinicopathologic parameters in 162 smoking patients with locally advanced stage IV head and neck squamous cell carcinoma receiving induction chemotherapy with TPF

From: Betel nut chewing history is an independent prognosticator for smoking patients with locally advanced stage IV head and neck squamous cell carcinoma receiving induction chemotherapy with docetaxel, cisplatin, and fluorouracil

Parameters

 

Betel nut chewing

  

Absent

Present

P value

Age

<53 years old

13

68

0.32

 

≧53 years old

18

63

 

Sex

Male

29

127

0.32

 

Female

2

4

 

Clinical 7th AJCC stage

IVA

17

63

0.50

 

IVB

14

68

 

Clinical T classification

T1~T4a

19

73

0.57

 

T4b

12

58

 

Clinical N classification

N0/1

8

40

0.60

 

N2/3

23

91

 

Primary tumor site

Oral cavity

11

51

0.72

 

Others

20

80

 

Primary tumor site

Oropharynx

10

50

0.54

 

Others

21

81

 

Primary tumor site

Larynx/hypopharynx

9

27

0.31

 

Others

22

104

 

p16 expression

Negative

27

101

0.21

 

Positive

1

2

 
 

Unknown

3

28

 

Alcohol

Absent

6

10

0.086

 

Present

25

121

 
  1. TPF, docetaxel, cisplatin, and fluorouracil
  2. х 2 test, Fisher’s exact test, or t test was used for statistically analyzed