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Table 2 Associations between betel nut chewing and clinicopathologic parameters in 162 smoking patients with locally advanced stage IV head and neck squamous cell carcinoma receiving induction chemotherapy with TPF

From: Betel nut chewing history is an independent prognosticator for smoking patients with locally advanced stage IV head and neck squamous cell carcinoma receiving induction chemotherapy with docetaxel, cisplatin, and fluorouracil

Parameters   Betel nut chewing
   Absent Present P value
Age <53 years old 13 68 0.32
  53 years old 18 63  
Sex Male 29 127 0.32
  Female 2 4  
Clinical 7th AJCC stage IVA 17 63 0.50
  IVB 14 68  
Clinical T classification T1~T4a 19 73 0.57
  T4b 12 58  
Clinical N classification N0/1 8 40 0.60
  N2/3 23 91  
Primary tumor site Oral cavity 11 51 0.72
  Others 20 80  
Primary tumor site Oropharynx 10 50 0.54
  Others 21 81  
Primary tumor site Larynx/hypopharynx 9 27 0.31
  Others 22 104  
p16 expression Negative 27 101 0.21
  Positive 1 2  
  Unknown 3 28  
Alcohol Absent 6 10 0.086
  Present 25 121  
  1. TPF, docetaxel, cisplatin, and fluorouracil
  2. х 2 test, Fisher’s exact test, or t test was used for statistically analyzed