Fig. 4From: IDH mutations may not preclude distant, trans-tentorial spread in gliomas: a case report and review of the literatureHistopathological features of the recurrent tumor. a A routine H&E stain showed histopathology similar to the initial tumor, including hypercellularity and anaplasia. b Immunohistochemical staining was again positive for the IDH1 (R132H) mutation. c MIB-1 immunohistochemical staining demonstrated a mitotic index of 40Â %, which was significantly elevated in comparison to the initial lesionBack to article page