Repeated cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with recurrent peritoneal carcinomatosis

Table 3 Comparable illustration of studies’ results concerned clinical and survival parameters in repeated CRS/HIPEC

Study	Number	type of primary	PCI	CC-0/1 (%)	Median time between first and second HIPEC (months)	Length of stay (days)	30-day morbidity (%)	30-day III/IV morbidity (%)	30-day mortality (%)	Median follow-up after repeated HIPEC (months)	Median overall survival after repeated HIPEC (months)	1J (%) after repeat HIPEC	3J (%) after repeat HIPEC	5J (%) after repeat HIPEC
Lubrano (2006) [41]	5	Various^a	n.a.	n.a.	n.a.	n.a.	30	n.a.	0	n.a.	n.a.	60	40	20
Brouquet (2009) [24]	20	Various^b	6	n.a.	17^j	15	60	30	5	63.2	n.a.	96	82	72.5
Saxena (2010)[42]	40	Various^c	n.a.	66	n.a.	32	80	35	2.5	n.a.	n.a.	n.a.	n.a.	n.a.
Golse (2012) [33]	30	Various^d	8	90	22	15	73.3	40.5	3.3	18	140^l	n.a.	n.a.	n.a.
Votano poulos (2012) [27]	62	Various^e	9	43.5	17^j	7.5	48.4	33.3	3.2	60.8	32.3	78.7	48.6	31.6
Chua (2013) [35]	79	Various^f	16	92.4	n.a.	29	n.a.	41	0	24	48	90	60	34
Sardi (2013) [37]	26	Appendiceal carcinoma	23	65	23	11	n.a.	42	0	28	46.5	90.9	54.3	33.9
Wong (2014)[36]	8	mesothelioma	13	100	15.6	8	50	25	0	56.7^k	80^k	100^k	88^k	64^k
Iheme landu (2015)[38]	44	mesothelioma	14	34.1	12.5	14	29.6	2.3	0	31^k	54^k	n.a.	61^k	46^k
Vaira (2014) [40]	16	Various^g	n.a.	n.a.	13^j	n.a.	43.7	18.7	n.a.	n.a.	n.a.	n.a.	n.a.	n.a.
Wong (2015) [39]	7	Various^h	12	100	20^j	12	28.5	14	0	13	20.7	85	43	29
Vassos (2016)(current study)	6	Variousⁱ	6	100	25.8	17	33	16	0	50	50	100

n.a. not available
^an.a.
^bPseudomyxoma, colorectal (CRC), mesothelioma, carcinoid
^cPseudomyxoma, CRC
^dPseudomyxoma, CRC, mesothelioma, ovarian cancer, gastric cancer, cholangiocarcinoma, leiomyosarcoma, primary peritoneal carcinoma
^eAppendiceal carcinoma, CRC, mesothelioma, ovarian cancer, gastric cancer, GIST, gallbladder carcinoma, small bowel carcinoma, leiomyosarcoma, urachal carcinoma
^fPseudomyxoma, CRC, pseudomyxoma, appendiceal carcinoma, small bowel carcinoma, ovarian cancer, hepatocellular carcinoma
^gPseudomyxoma, CRC, mesothelioma, ovarian cancer
^hAppendiceal carcinoma, CRC, mesothelioma, ovarian cancer
ⁱAppendiceal carcinoma, CRC, mesothelioma, ovarian cancer, uterine sarcoma
^jMedian time till diagnosis of recurrent PC
^kTime period estimating from first CRS/HIPEC
^lTime period estimating from diagnosis

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