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Table 2 Correlation of clinicopathological/morphological parameters and HIF-1α/HIF-2α expression

From: Expression of HIF-1α and HIF-2α correlates to biological and clinical significance in papillary thyroid carcinoma

Clinical Characteristics PTC HIF-1α   HIF-2α  
Total (+)   (+)  
n (%) n (%)   n (%)  
92 (100 %) 67 (73 %) P value 60 (65 %) P value
Gender      
 Female 64 (70) 49 (67)   41 (64)  
 Male 28 (30) 18 (64) 0.223 19 (68) 0.725
Age (year)      
  ≥ 45 49 (53) 36 (74)   31 (63)  
  < 45 43 (47) 31 (72) 0.882 29 (67) 0.675
Tumor size (cm)      
  ≥ 1 42 (40) 30 (71)   32 (76)  
  < 1 50 (60) 37 (74) 0.782 28 (56) 0.043*
Lymph node metastasis      
 Yes 51 (55) 43 (84)   38 (75)  
 No 41 (45) 24 (59) 0.006* 22 (54) 0.037*
Calcification      
 Yes 35 (38) 23 (66)   21 (60)  
 No 57 (62) 44 (77) 0.230 39 (68) 0.410
Capsular invasion      
 Yes 56 (61) 46 (82)   43 (77)  
 No 36 (39) 21 (58) 0.012* 17 (47) 0.004*
TNM stage      
 I–II 52 (59) 33 (64)   28 (51)  
 III–IV 40 (41) 34 (85) 0.021* 32 (77) 0.009*
Hashimoto’s disease      
 Yes 62 (67) 47 (76)   38 (61)  
 No 30 (33) 20 (67) 0.463 22 (73) 0.256
  1. HIF hypoxia-inducible factor
  2. *P < 0.05