Table 2 Correlation of clinicopathological/morphological parameters and HIF-1α/HIF-2α expression
Clinical Characteristics | PTC | HIF-1α | HIF-2α | ||
|---|---|---|---|---|---|
Total | (+) | (+) | |||
n (%) | n (%) | n (%) | |||
92 (100 %) | 67 (73 %) | P value | 60 (65 %) | P value | |
Gender | |||||
Female | 64 (70) | 49 (67) | 41 (64) | ||
Male | 28 (30) | 18 (64) | 0.223 | 19 (68) | 0.725 |
Age (year) | |||||
≥ 45 | 49 (53) | 36 (74) | 31 (63) | ||
< 45 | 43 (47) | 31 (72) | 0.882 | 29 (67) | 0.675 |
Tumor size (cm) | |||||
≥ 1 | 42 (40) | 30 (71) | 32 (76) | ||
< 1 | 50 (60) | 37 (74) | 0.782 | 28 (56) | 0.043* |
Lymph node metastasis | |||||
Yes | 51 (55) | 43 (84) | 38 (75) | ||
No | 41 (45) | 24 (59) | 0.006* | 22 (54) | 0.037* |
Calcification | |||||
Yes | 35 (38) | 23 (66) | 21 (60) | ||
No | 57 (62) | 44 (77) | 0.230 | 39 (68) | 0.410 |
Capsular invasion | |||||
Yes | 56 (61) | 46 (82) | 43 (77) | ||
No | 36 (39) | 21 (58) | 0.012* | 17 (47) | 0.004* |
TNM stage | |||||
I–II | 52 (59) | 33 (64) | 28 (51) | ||
III–IV | 40 (41) | 34 (85) | 0.021* | 32 (77) | 0.009* |
Hashimoto’s disease | |||||
Yes | 62 (67) | 47 (76) | 38 (61) | ||
No | 30 (33) | 20 (67) | 0.463 | 22 (73) | 0.256 |