Fig. 4

Gross appearance of resected uterus, histopathology, and immunohistochemistry of sections of uterine cervical tumor and cecal tumor specimens. a Gross appearance of the resected uterus. Note that the mucosal surface of the endocervical canal is clear (red arrow). b Hematoxylin and eosin staining of the cervical tumor specimen demonstrates invasive growth of irregular and atypical ductal hyperplasia with moderate differentiation (original magnification ×200). c Cervical carcinoma shows diffuse and strongly positive CK7 staining (original magnification ×100). d Cervical carcinoma is negative for CK20 staining (original magnification ×100). e Cervical carcinoma cells show diffuse and strongly positive CDX2 nuclear staining (original magnification ×200). f Hematoxylin-and-eosin-stained section of the cecal adenocarcinoma demonstrates well-differentiated adenocarcinoma (yellow arrowheads). Note that normal crypt architecture is seen on the left side of the picture (red arrows) (original magnification ×100). g Cecal carcinoma shows diffuse and strongly positive CK7 staining (original magnification ×100). h Cecal carcinoma is negative for CK20 staining. Note that normal crypt architecture is positive for CK20 staining (original magnification ×100). i Cecal carcinoma shows diffuse and strongly positive CDX2 nuclear staining (original magnification ×200)