Table 1 Comparison of studies with regards to interventions for colorectal cancer
Authors | Year | Number of patients | Intervention evaluated | Main conclusions |
|---|---|---|---|---|
You et al. | 2008 | 522 | Quality of life (QOL) after extended (201) vs segmental (321) colon resection | Extended resection yielded compromised bowel function, with decreased QOL |
Zhang et al. | 2013 | 14 | En bloc pancreaticoduodenectomy (PD) and right hemicolectomy in right colon cancer | Outcomes no worse than stage-matched patients without adjacent organ involvement |
Temple et al. | 2014 | 635 | PD (607) vs PD with colon resection (28) | No significant difference in post-operative mortality |
Cirocchi et al. | 2014 | 53 | En bloc (39) vs local resection (14) in locally advanced right colon cancer | En bloc resection improved overall 5-year survival |
Kalady et al. | 2010 | 296 | Segmental (253) vs total colectomy (43) in HNPCC | Segmental resection increases the risk of metachronous colon cancer |
Berg et al. | 2013 | 204 | Impact of tumor genetics on lymph node harvest in stage I–III colon cancer | Node harvest was greatest for cancers with MSI but without KRAS/BRAF |
Samdani et al. | 2015 | 256 | Effect of mismatch repair deficiency on lymph node yield in colorectal cancer | Mismatch repair deficiency did not predict lymph node yield |
Sugimoto et al. | 2015 | 4172 | Prognostic value of lymph node ratio in stage III colon cancer | Lymph node ratio, with a cutoff value of 0.18, was a significant independent prognostic factor |
Hong et al. | 2014 | 321 | Comparison of adjuvant chemotherapy (fluorouracil and leucovorin (161) vs FOLFOX (160)) in stage II–III rectal cancer after neoadjuvant chemoradiotherapy and resection | Adjuvant FOLFOX improved survival compared to adjuvant fluorouracil and leucovorin |
de Vos tot Nederveen Cappel et al. | 2004 | 92 | Effect of adjuvant therapy with 5-FU (28) vs no adjuvant therapy (64) in stage III colon cancer of HNPCC | 5-year survival did not differ |