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Table 1 Comparison of studies with regards to interventions for colorectal cancer

From: Pancreaticoduodenectomy for locally advanced colon cancer in hereditary nonpolyposis colorectal cancer

Authors Year Number of patients Intervention evaluated Main conclusions
You et al. 2008 522 Quality of life (QOL) after extended (201) vs segmental (321) colon resection Extended resection yielded compromised bowel function, with decreased QOL
Zhang et al. 2013 14 En bloc pancreaticoduodenectomy (PD) and right hemicolectomy in right colon cancer Outcomes no worse than stage-matched patients without adjacent organ involvement
Temple et al. 2014 635 PD (607) vs PD with colon resection (28) No significant difference in post-operative mortality
Cirocchi et al. 2014 53 En bloc (39) vs local resection (14) in locally advanced right colon cancer En bloc resection improved overall 5-year survival
Kalady et al. 2010 296 Segmental (253) vs total colectomy (43) in HNPCC Segmental resection increases the risk of metachronous colon cancer
Berg et al. 2013 204 Impact of tumor genetics on lymph node harvest in stage I–III colon cancer Node harvest was greatest for cancers with MSI but without KRAS/BRAF
Samdani et al. 2015 256 Effect of mismatch repair deficiency on lymph node yield in colorectal cancer Mismatch repair deficiency did not predict lymph node yield
Sugimoto et al. 2015 4172 Prognostic value of lymph node ratio in stage III colon cancer Lymph node ratio, with a cutoff value of 0.18, was a significant independent prognostic factor
Hong et al. 2014 321 Comparison of adjuvant chemotherapy (fluorouracil and leucovorin (161) vs FOLFOX (160)) in stage II–III rectal cancer after neoadjuvant chemoradiotherapy and resection Adjuvant FOLFOX improved survival compared to adjuvant fluorouracil and leucovorin
de Vos tot Nederveen Cappel et al. 2004 92 Effect of adjuvant therapy with 5-FU (28) vs no adjuvant therapy (64) in stage III colon cancer of HNPCC 5-year survival did not differ