Table 2 Thyroid nodule characteristics according to their histopathologic findings; p value displayed as well-differentiated thyroid cancer vs. benign findings
From: Rapid thyroid nodule growth is not a marker for well-differentiated thyroid cancer
Benign | Well differentiated thyroid cancer | Secondary malignancy | Malignant total | p value | |||
|---|---|---|---|---|---|---|---|
Papillary | Follicular | Total | |||||
N | 260 | 27 | 6 | 33 | 4 | 37 | |
Nodularity | |||||||
Uninodular | 36 (14 %) | 12 | 1 | 13 (39 %) | 2 | 15 | 0.001 |
Multinodular | 224 (86 %) | 15 | 5 | 20 (61 %) | 2 | 22 | |
Initial nodule volume >2 cm3 | 185 (71 %) | 10 | 5 | 15 (45 %) | 2 | 17 | 0.004 |
Nodule volume >2 cm3 at last follow-up | 226 (87 %) | 12 | 6 | 18 (55 %) | 3 | 21 | 0.001 |
Median months ultrasound follow-up of nodule before surgery | 28 [6–89] | 31 [6–53] | 11 [6–26] | 0.001 | |||
Sonomorphologic change in nodule pattern | |||||||
Hypoechogenity | 24 (9 %) | 5 | 1 | 6 (18 %) | 3 | 9 | 0.237 |
Microcalcification | 12 (4.6 %) | 6 | 1 | 7 (21 %) | 0 | 7 | 0.004 |
Taller than wide | 11 (4.2 %) | 3 | 2 | 5 (15 %) | 2 | 7 | 0.036 |
Irregular nodule margins | 5 (2 %) | 1 | 0 | 1 (3 %) | 1 | 2 | 0.553 |
Suppressive therapy with levothyroxine and/or iodine | 109 (42 %) | 17 | 2 | 19 (58 %) | 1 | 20 | 0.292 |