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Table 4 Clinical characteristics in n = 304 patients with no chemotherapy, perioperative and downsizing chemotherapy in conjunction with resection for colorectal liver metastases

From: Predictive factors for time to recurrence, treatment and post-recurrence survival in patients with initially resected colorectal liver metastases

Variable No chemo (n = 199) Perioperative (n = 59) Downsizing (n = 46) p
No. of mets (mean/median) 2.1/1 2.4/2 3.4/3 0.001a
Mets size (cm, median) 3.5/3 2.8/2.1 4.1/3.5 0.003a
Age (year, mean/median) 65.9/66.5 63.7/65.1 62.0/63.6 0.055b
R1 (n, %) 40 (20.2) 12 (20.7) 10 (21.7) 0.973c
N-pos primary (n, %) 68 (36.0) 19 (32.8) 21 (46.7) 0.311c
Clavien-Dindo (1–5) 61 (31.3) 24 (41.4) 16 (35.6) 0.350c
ASA (1/2/3) 20/136/43 5/50/4 2/34/10 0.069c
Synch. mets (n, %) 71 (35.7) 36 (61.0) 30 (65.2) 0.001c
Gender (M/F) 104/95 36/23 26/20 0.475c
Recurrence pattern (n, A/B) 53/82 15/18 20/15 0.256c
  1. Seven of 311 patients had progress on chemotherapy after stage III colon cancer, not included in the analysis
  2. A hepatic recurrence, B extrahepatic recurrence
  3. aKruskal-Wallis test
  4. bOne-way analysis of variance
  5. c χ 2 test