Skip to main content

Table 3 Cox regression analysis of factors affecting time to hepatic and extrahepatic recurrence

From: Predictive factors for time to recurrence, treatment and post-recurrence survival in patients with initially resected colorectal liver metastases

  Hepatic recurrence Extrahepatic recurrencea
  Multivariate
Variable HR 95 % CI p HR 95 % CI p
Age/10 years 1.00 (0.81, 1.24) 0.995 1.14 (0.95, 1.37) 0.165
Synch. mets
 No 1.00 Reference 0.002 1.00 Reference 0.499
 Yes 2.07 (1.28, 3.33)   1.15 (0.77, 1.73)  
No. of mets 1.20 (1.07, 1.35) 0.005 1.27 (1.14, 1.41) <0.001
Mets diam (cm) 0.99 (0.88, 1.10) 0.828 1.16 (1.07, 1.27) 0.001
RM status
 R0 1.00 Reference 0.010 1.00 Reference 0.769
 R1 2.00 (1.20, 3.31)   0.93 (0.57, 1.52)  
ASA score
 (1–3) 1.69 (1.08, 2.64) 0.021 1.24 (0.85, 1.81) 0.264
 Clavien-Dindo 0.99 (0.83, 1.19) 0.958 1.12 (0.96, 1.30) 0.165
N-pos
 No 1.00 Reference 0.652 1.00 Reference 0.007
 Yes 0.90 (0.58, 1.41)   1.79 (1.16, 2.76)  
Chemotherapy
 None 1.00 Reference 0.143 1.00 Reference 0.036
 Periop. 0.63 (0.34, 1.18)   0.64 (0.37, 1.11)  
 Downsiz. 1.36 (0.78, 2.39)   0.63 (0.35, 1.14)  
 Adj. colon 2.28 (0.54, 9.60)   3.12 (1.10, 8.84)  
  1. Unknown N status n = 12. Unknown RM n = 2
  2. RM resection margins, HR hazard ratio, CI confidence interval
  3. aExtrahepatic recurrence also included combined hepatic and extrahepatic recurrence