Table 3 Cox regression analysis of factors affecting time to hepatic and extrahepatic recurrence
Hepatic recurrence | Extrahepatic recurrencea | |||||
|---|---|---|---|---|---|---|
Multivariate | ||||||
Variable | HR | 95 % CI | p | HR | 95 % CI | p |
Age/10 years | 1.00 | (0.81, 1.24) | 0.995 | 1.14 | (0.95, 1.37) | 0.165 |
Synch. mets | ||||||
No | 1.00 | Reference | 0.002 | 1.00 | Reference | 0.499 |
Yes | 2.07 | (1.28, 3.33) | 1.15 | (0.77, 1.73) | ||
No. of mets | 1.20 | (1.07, 1.35) | 0.005 | 1.27 | (1.14, 1.41) | <0.001 |
Mets diam (cm) | 0.99 | (0.88, 1.10) | 0.828 | 1.16 | (1.07, 1.27) | 0.001 |
RM status | ||||||
R0 | 1.00 | Reference | 0.010 | 1.00 | Reference | 0.769 |
R1 | 2.00 | (1.20, 3.31) | 0.93 | (0.57, 1.52) | ||
ASA score | ||||||
(1–3) | 1.69 | (1.08, 2.64) | 0.021 | 1.24 | (0.85, 1.81) | 0.264 |
Clavien-Dindo | 0.99 | (0.83, 1.19) | 0.958 | 1.12 | (0.96, 1.30) | 0.165 |
N-pos | ||||||
No | 1.00 | Reference | 0.652 | 1.00 | Reference | 0.007 |
Yes | 0.90 | (0.58, 1.41) | 1.79 | (1.16, 2.76) | ||
Chemotherapy | ||||||
None | 1.00 | Reference | 0.143 | 1.00 | Reference | 0.036 |
Periop. | 0.63 | (0.34, 1.18) | 0.64 | (0.37, 1.11) | ||
Downsiz. | 1.36 | (0.78, 2.39) | 0.63 | (0.35, 1.14) | ||
Adj. colon | 2.28 | (0.54, 9.60) | 3.12 | (1.10, 8.84) | ||