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Table 2 Cox regression analysis of factors affecting time to overall recurrence

From: Predictive factors for time to recurrence, treatment and post-recurrence survival in patients with initially resected colorectal liver metastases

   Overall recurrence (TTR)  
   Univariate Multivariate
Variable n HR 95 % CI p HR 95 % CI p
Age/10 years 311 1.11 (0.98, 1.26) 0.113 1.08 (0.94, 1.25) 0.253
Synch. mets
 No 154 1.00 Reference 0.002 1.00 Reference 0.010
 Yes 157 1.65 (1.25, 2.17)   1.50 (1.10, 2.04)  
No. of mets 311 1.21 (1.14, 1.30) <0.001 1.24 (1.14, 1.34) <0.001
Mets diam (cm) 311 1.11 (1.04, 1.18) 0.002 1.08 (1.01, 1.16) 0.022
RM status
 R0 246 1.00 Reference 0.013 1.00 Reference 0.143
 R1 63 1.53 (1.11, 2.11)   1.30 (0.92, 1.84)  
ASA score (1–3) 311 1.28 (1.00, 1.65) 0.054 1.40 (1.05, 1.87) 0.022
Clavien-Dindo 311 1.12 (1.01, 1.25) 0.037 1.07 (0.95, 1.20) 0.267
N-posa
 No 190 1.00 Reference 0.058 1.00 Reference 0.091
 Yes 109 1.32 (0.99, 1.78)   1.30 (0.96, 1.77)  
Chemotherapy
 None 199 1.00 Reference 0.010 1.00 Reference 0.014
 Periop. 59 0.71 (0.49, 1.05)   0.63 (0.42, 0.95)  
 Downsiz. 46 1.31 (0.90, 1.89)   0.93 (0.62, 1.39)  
 Adj. colonb 7 2.98 (1.31, 6.79)   2.80 (1.21, 6.48)  
  1. Unknown N status n = 12. Unknown RM n = 2
  2. RM resection margins, HR hazard ratio, CI confidence interval
  3. aN-pos: positive lymph nodes of the primary tumour in colon or rectum
  4. bAdj. colon: adjuvant chemotherapy after surgery for stage III (node positive) colon cancer