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Table 2 Cox regression analysis of factors affecting time to overall recurrence

From: Predictive factors for time to recurrence, treatment and post-recurrence survival in patients with initially resected colorectal liver metastases

  

Overall recurrence (TTR)

 
  

Univariate

Multivariate

Variable

n

HR

95 % CI

p

HR

95 % CI

p

Age/10 years

311

1.11

(0.98, 1.26)

0.113

1.08

(0.94, 1.25)

0.253

Synch. mets

 No

154

1.00

Reference

0.002

1.00

Reference

0.010

 Yes

157

1.65

(1.25, 2.17)

 

1.50

(1.10, 2.04)

 

No. of mets

311

1.21

(1.14, 1.30)

<0.001

1.24

(1.14, 1.34)

<0.001

Mets diam (cm)

311

1.11

(1.04, 1.18)

0.002

1.08

(1.01, 1.16)

0.022

RM status

 R0

246

1.00

Reference

0.013

1.00

Reference

0.143

 R1

63

1.53

(1.11, 2.11)

 

1.30

(0.92, 1.84)

 

ASA score (1–3)

311

1.28

(1.00, 1.65)

0.054

1.40

(1.05, 1.87)

0.022

Clavien-Dindo

311

1.12

(1.01, 1.25)

0.037

1.07

(0.95, 1.20)

0.267

N-posa

 No

190

1.00

Reference

0.058

1.00

Reference

0.091

 Yes

109

1.32

(0.99, 1.78)

 

1.30

(0.96, 1.77)

 

Chemotherapy

 None

199

1.00

Reference

0.010

1.00

Reference

0.014

 Periop.

59

0.71

(0.49, 1.05)

 

0.63

(0.42, 0.95)

 

 Downsiz.

46

1.31

(0.90, 1.89)

 

0.93

(0.62, 1.39)

 

 Adj. colonb

7

2.98

(1.31, 6.79)

 

2.80

(1.21, 6.48)

 
  1. Unknown N status n = 12. Unknown RM n = 2
  2. RM resection margins, HR hazard ratio, CI confidence interval
  3. aN-pos: positive lymph nodes of the primary tumour in colon or rectum
  4. bAdj. colon: adjuvant chemotherapy after surgery for stage III (node positive) colon cancer