Overexpression of G6PD is associated with high risks of recurrent metastasis and poor progression-free survival in primary breast carcinoma

Table 4 Multivariate analyses of progression-free survival (PFS) and overall survival (OS) in patients with breast carcinoma

Variables	PFS			OS
Variables	P value	Hazard ratio (HR)	95 % CI	P value	HR	95 % CI
G6PD (negative vs. positive expression)	0.021	13.488	1.472–123.554	0.398	2.695	0.271–26.815
PKM2 (negative vs. positive expression)	0.835	1.304	0.107–15.868	0.674	1.916	0.093–39.686
Tumor staging
I	0.095			0.977
II	0.241	0.262	0.028–2.461	0.963	–	–
III	0.375	2.691	0.303–23.938	0.964	–	–
Tumor size (≤2 cm vs. >2 cm)	0.946	0.000	–	0.900	–	–

Cox regression analysis (Enter method) was used to assess prognostic factors associated with PFS and OS. A hazard ratio >1 with P < 0.05 indicates a greater likelihood of development of breast carcinoma, while a hazard ratio <1 with P < 0.05 indicates a lesser likelihood of development of breast carcinoma. A hazard ratio = 1 with P < 0.05 indicates that the given factor could not affect the development of breast carcinoma, but was significant in multivariate logistic regression model

ISSN: 1477-7819