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Table 4 Multivariate analysis of factors predicting disease-free and overall survival

From: Preoperative neutrophil/lymphocyte ratio and prognostic nutritional index predict survival in patients with non-small cell lung cancer

Disease-free survival
  Univariate Multivariate
  HR 95 % CI P value HR 95 % CI P value
Sex
 Male/female 1.70 1.08–2.69 0.023 1.37 0.85–2.19 0.187
Age
 >70/70 2.42 1.58–3.71 <0.001 1.94 1.24–3.04 0.004
Tumor size
 T2–3/T1 2.25 1.47–3.45 <0.001 1.14 0.74–1.76 0.560
Nodal metastasis
 Positive/negative 6.50 4.30–9.80 <0.001 6.42 4.16–9.89 <0.001
Histological type
 AD/non-AD 1.45 0.95–2.20 0.083 0.72 0.46–1.13 0.150
Tumor differentiation
 Mod+por/well 2.71 1.65–4.44 <0.001 1.69 1.01–2.83 0.047
NLR
 ≥2.5/<2.5 2.09 1.40–3.12 <0.001 1.58 1.02–2.43 0.039
PNI
 <50/≥50 2.28 1.52–3.42 <0.001 1.88 1.19–2.97 0.007
Overall survival
Sex
 Male/female 1.76 1.04–2.97 0.035 1.19 0.67–2.10 0.554
Age       
 >70/70 3.54 2.07–6.05 <0.001 2.31 1.30–4.08 0.004
Tumor size
 T2-3/T1 2.60 1.56–4.31 <0.001 1.45 0.85–2.46 0.171
Nodal metastasis
 Positive/negative 4.21 2.62-6.74 <0.001 3.78 2.34–6.13 <0.001
Histological type
 AD/non-AD 1.20 1.05–1.36 0.006 1.07 0.92–1.24 0.373
Tumor differentiation
 Mod+por/well 2.81 1.59–4.99 <0.001 1.60 0.85–3.02 0.143
NLR
 ≥2.5/<2.5 1.81 1.14–2.87 0.012 1.60 1.04–2.54 0.048
PNI
 <50/≥50 3.37 2.07–5.48 <0.001 2.40 1.39–4.14 0.002
  1. NLR neutrophil/lymphocyte ratio, PNI prognostic nutritional index, AD adenocarcinoma, mod+por moderate+poorly