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Table 4 Multivariate analysis of factors predicting disease-free and overall survival

From: Preoperative neutrophil/lymphocyte ratio and prognostic nutritional index predict survival in patients with non-small cell lung cancer

Disease-free survival

 

Univariate

Multivariate

 

HR

95 % CI

P value

HR

95 % CI

P value

Sex

 Male/female

1.70

1.08–2.69

0.023

1.37

0.85–2.19

0.187

Age

 >70/70

2.42

1.58–3.71

<0.001

1.94

1.24–3.04

0.004

Tumor size

 T2–3/T1

2.25

1.47–3.45

<0.001

1.14

0.74–1.76

0.560

Nodal metastasis

 Positive/negative

6.50

4.30–9.80

<0.001

6.42

4.16–9.89

<0.001

Histological type

 AD/non-AD

1.45

0.95–2.20

0.083

0.72

0.46–1.13

0.150

Tumor differentiation

 Mod+por/well

2.71

1.65–4.44

<0.001

1.69

1.01–2.83

0.047

NLR

 ≥2.5/<2.5

2.09

1.40–3.12

<0.001

1.58

1.02–2.43

0.039

PNI

 <50/≥50

2.28

1.52–3.42

<0.001

1.88

1.19–2.97

0.007

Overall survival

Sex

 Male/female

1.76

1.04–2.97

0.035

1.19

0.67–2.10

0.554

Age

      

 >70/70

3.54

2.07–6.05

<0.001

2.31

1.30–4.08

0.004

Tumor size

 T2-3/T1

2.60

1.56–4.31

<0.001

1.45

0.85–2.46

0.171

Nodal metastasis

 Positive/negative

4.21

2.62-6.74

<0.001

3.78

2.34–6.13

<0.001

Histological type

 AD/non-AD

1.20

1.05–1.36

0.006

1.07

0.92–1.24

0.373

Tumor differentiation

 Mod+por/well

2.81

1.59–4.99

<0.001

1.60

0.85–3.02

0.143

NLR

 ≥2.5/<2.5

1.81

1.14–2.87

0.012

1.60

1.04–2.54

0.048

PNI

 <50/≥50

3.37

2.07–5.48

<0.001

2.40

1.39–4.14

0.002

  1. NLR neutrophil/lymphocyte ratio, PNI prognostic nutritional index, AD adenocarcinoma, mod+por moderate+poorly