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Table 5 Association between the selected SNPs in pre-microRNAs and metastasis

From: Common genetic polymorphisms in pre-microRNAs and risk of bladder cancer

Genetic model

Genotype

Metastasis

No metastasis

Logistic regressiona

n = 132

n = 27

OR (95 % CI)

P

mir-196a2 rs11614913 C/T

Codominant

T/T

40 (30.3 %)

12 (44.4 %)

1

0.28

C/T

56 (42.4 %)

10 (37 %)

1.33 (0.47–3.85)

C/C

36 (27.3 %)

5 (18.5 %)

2.63 (0.77–9.09)

Dominant

T/T

40 (30.3 %)

12 (44.4 %)

1

0.23

C/T-C/C

92 (69.7 %)

15 (55.6 %)

1.75 (0.70–4.35)

Recessive

T/T-C/T

96 (72.7 %)

22 (81.5 %)

1

0.13

C/C

36 (27.3 %)

5 (18.5 %)

2.33 (0.74–7.14)

Overdominant

T/T-C/C

76 (57.6 %)

17 (63 %)

1

0.87

C/T

56 (42.4 %)

10 (37 %)

1.08 (0.42–2.81)

Log-additive

0.63 (0.35–1.14)

0.12

mir-499 rs3746444 G/A

Codominant

A/A

89 (67.4 %)

18 (66.7 %)

1

0.37

G/A

38 (28.8 %)

7 (25.9 %)

1.72 (0.60–5.00)

G/G

5 (3.8 %)

2 (7.4 %)

0.46 (0.06–3.45)

Dominant

A/A

89 (67.4 %)

18 (66.7 %)

1

0.45

G/A-G/G

43 (32.6 %)

9 (33.3 %)

0.69 (0.26–1.86)

Recessive

A/A-G/A

127 (96.2 %)

25 (92.6 %)

1

0.35

G/G

5 (3.8 %)

2 (7.4 %)

0.37 (0.05–2.70)

Overdominant

A/A-G/G

94 (71.2 %)

20 (74.1 %)

1

0.23

G/A

38 (28.8 %)

7 (25.9 %)

1.85 (0.65–5.26)

Log-additive

0.89 (0.39–2.04)

0.78

mir146a rs2910164 C/G

Codominant

C/C

46 (34.9 %)

14 (51.9 %)

1

0.081

C/G

62 (47 %)

11 (40.7 %)

2.27 (0.83–6.25)

G/G

24 (18.2 %)

2 (7.4 %)

5.00 (0.86–25.00)

Dominant

C/G

46 (34.9 %)

14 (51.9 %)

1

0.04

C/G-G/G

86 (65.2 %)

13 (48.1 %)

2.63 (1.03–6.67)

Recessive

C/G-C/G

108 (81.8 %)

25 (92.6 %)

1

0.12

G/G

24 (18.2 %)

2 (7.4 %)

3.33 (0.62–16.67)

Overdominant

C/C-G/G

70 (53 %)

16 (59.3 %)

1

0.31

C/G

62 (47 %)

11 (40.7 %)

1.61 (0.63–4.17)

Log-additive

0.45 (0.21–0.93)

0.025

  1. aAdjusted by gender, age, smoking status, tumor stage, recurrence, and metastasis. Italicized values indicated a significant difference at the 5 % level
  2. n number of individuals