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Table 4 Association between the selected SNPs in pre-microRNAs and tumor stage

From: Common genetic polymorphisms in pre-microRNAs and risk of bladder cancer

Genetic model

Genotype

Invasive

Superficial

Logistic regressiona

n = 84

n = 75

OR (95 % CI)

P

mir-196a2 rs11614913 C/T

Codominant

T/T

27 (32.1 %)

25 (33.3 %)

1

0.68

C/T

33 (39.3 %)

33 (44 %)

0.63 (0.21–1.86)

C/C

24 (28.6 %)

17 (22.7 %)

1.45 (0.43–5.00)

Dominant

T/T

27 (32.1 %)

25 (33.3 %)

1

0.39

C/T-C/C

57 (67.9 %)

50 (66.7 %)

0.65 (0.24–1.74)

Recessive

T/T-C/T

60 (71.4 %)

58 (77.3 %)

1

0.83

C/C

24 (28.6 %)

17 (22.7 %)

1.12 (0.39–3.23)

Overdominant

T/T-C/C

51 (60.7 %)

42 (56 %)

1

0.52

C/T

33 (39.3 %)

33 (44 %)

0.74 (0.28–1.91)

Log-additive

0.82 (0.45–1.49)

0.51

mir-499 rs3746444 G/A

Codominant

A/A

52 (61.9 %)

55 (73.3 %)

1

0.25

G/A

28 (33.3 %)

17 (22.7 %)

1.96 (0.67–5.88)

G/G

4 (4.8 %)

3 (4 %)

3.70 (0.50–25.00)

Dominant

A/A

52 (61.9 %)

55 (73.3 %)

1

0.12

G/A-G/G

32 (38.1 %)

20 (26.7 %)

2.22 (0.81–5.88)

Recessive

A/A-A/A

80 (95.2 %)

72 (96 %)

1

0.26

G/G

4 (4.8 %)

3 (4 %)

3.13 (0.44–25.00)

Overdominant

A/A-G/G

56 (66.7 %)

58 (77.3 %)

1

0.27

G/A

28 (33.3 %)

17 (22.7 %)

1.82 (0.63–0.92)

Log-additive

0.51 (0.23–1.13)

0.094

mir146a rs2910164 C/G

    

Codominant

C/C

30 (35.7 %)

30 (40 %)

1

0.034

C/G

45 (53.6 %)

28 (37.3 %)

1.41 (0.50–4.00)

G/G

9 (10.7 %)

17 (22.7 %)

0.24 (0.06–1.01)

Dominant

C/C

30 (35.7 %)

30 (40 %)

1

0.84

C/G-G/G

54 (64.3 %)

45 (60 %)

1.11 (0.42–2.89)

Recessive

C/C-C/G

75 (89.3 %)

58 (77.3 %)

1

0.012

G/G

9 (10.7 %)

17 (22.7 %)

0.20 (0.05–0.72)

Overdominant

C/C-G/G

39 (46.4 %)

47 (62.7 %)

1

0.097

C/G

45 (53.6 %)

28 (37.3 %)

2.17 (0.86–5.56)

Log-additive

1.66 (0.84–3.31)

0.14

  1. aAdjusted by gender, age, smoking status, tumor stage, recurrence, and metastasis. Italicized values indicated a significant difference at the 5 % level
  2. n number of individuals