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Table 3 Genotype frequencies of selected SNPs in pre-microRNAs among bladder cancer patients and controls and their association with bladder cancer risk

From: Common genetic polymorphisms in pre-microRNAs and risk of bladder cancer

Genetic model

Genotype

Patients

Controls

Logistic regressiona

n = 159 (%)

n = 298 (%)

OR (95 % CI)

P

mir-196a2 rs11614913 C/T

Codominant

T/T

52 (32.7 %)

76 (25.5 %)

1

0.015

C/T

66 (41.5 %)

166 (55.7 %)

0.58 (0.37–0.92)

C/C

41 (25.8 %)

56 (18.8 %)

1.08 (0.63–1.82)

Dominant

T/T

52 (32.7 %)

76 (25.5 %)

1

0.1

C/T-C/C

107 (67.3 %)

222 (74.5 %)

0.70 (0.46–1.08)

Recessive

T/T-C/T

118 (74.2 %)

242 (81.2 %)

1

0.085

C/C

41 (25.8 %)

56 (18.8 %)

1.49 (0.95–2.38)

Overdominant

T/T-C/C

93 (58.5 %)

132 (44.3 %)

1

0.004

C/T

66 (41.5 %)

166 (55.7 %)

0.56 (0.38–0.83)

Log-additive

1.00 (0.76–1.32)

0.98

mir-499 rs3746444 G/A

Codominant

A/A

107 (67.3 %)

216 (72.5 %)

1

0.44

G/A

45 (28.3 %)

68 (22.8 %)

1.33 (0.86–2.08)

G/G

7 (4.4 %)

14 (4.7 %)

0.99 (0.39–2.53)

Dominant

A/A

107 (67.3 %)

216 (72.5 %)

1

0.25

G/A-G/G

52 (32.7 %)

82 (27.5 %)

1.28 (0.84–1.96)

Recessive

A/A-G/A

152 (95.6 %)

284 (95.3 %)

1

0.89

G/G

7 (4.4 %)

14 (4.7 %)

0.93 (0.37–2.38)

Overdominant

A/A-G/G

114 (71.7 %)

230 (77.2 %)

1

0.2

G/A

45 (28.3 %)

68 (22.8 %)

1.33 (0.86–2.08)

Log-additive

0.86 (0.61–1.20)

0.38

mir146a rs2910164 C/G

Codominant

C/C

60 (37.7 %)

112 (37.6 %)

1

0.2

C/G

73 (45.9 %)

154 (51.7 %)

0.88 (0.58–1.35)

G/G

26 (16.4 %)

32 (10.7 %)

1.52 (0.83–2.78)

Dominant

C/C

60 (37.7 %)

112 (37.6 %)

1

0.97

C/G-G/G

99 (62.3 %)

186 (62.4 %)

0.99(0.67–1.47)

Recessive

C/C-C/G

133 (83.7 %)

266 (89.3 %)

1

0.091

G/G

26 (16.4 %)

32 (10.7 %)

1.61 (0.93–2.86)

Overdominant

C/C-G/G

86 (54.1 %)

144 (48.3 %)

1

0.24

C/G

73 (45.9 %)

154 (51.7 %)

0.79 (0.54–1.16)

Log-additive

0.88 (0.66–1.18)

0.4

  1. aAdjusted by gender, age, smoking status, tumor stage, recurrence, and metastasis. Italicized values indicated a significant difference at the 5 % level
  2. n number of individuals