Table 1 Clinical and tumour data of patients
Colorectal cancer | Colorectal cancer | Allred score negative | Allred score positive | p value | |
|---|---|---|---|---|---|
(n = 138) | (n = 134) | (n = 40) | (n = 98) | ||
Gender | 0.087c | ||||
Females | 55 (39.9 %) | 55 (41 %) | 20 (50 %) | 35 (35.7 %) | |
Males | 83 (60.1 %) | 79 (59 %) | 20 (50 %) | 63 (64.3 %) | |
Average age (year) | 64 SD ±10 | 64 SD ±10 | 65 SD ±10 | 64 SD ±10 | 0.662d |
Dukes pathology | 0.819c | ||||
A | 30 (21.7 %) | 29 (21.6 %) | 10 (25 %) | 20 (20.4 %) | |
B | 45 (32.6 %) | 43 (32.1 %) | 13 (32.5 %) | 32 (32.7 %) | |
C | 63 (45.7 %) | 62 (46.3 %) | 17 (42.5 %) | 46 (46.9 %) | |
TNM clinical stage | 0.929c | ||||
I | 29 (21 %) | 28 (20.9 %) | 9 (22.5 %) | 20 (20.4 %) | |
II | 43 (31.2 %) | 41 (30.6 %) | 12 (30 %) | 31 (31.6 %) | |
III | 45 (32.6 %) | 44 (32.8 %) | 14 (35 %) | 31 (31.6 %) | |
IV | 21 (15.2 %) | 21 (15.7 %) | 5 (12.5 %) | 16 (16.4 %) | |
Tumour grade (n = 136a; n = 132b) | 0.373c | ||||
Low grade | 108a (79.4 %) | 106b (80.3 %) | 33 (82.5 %) | 75 (76.5 %) | |
High grade | 28a (20.6 %) | 26b (19.7 %) | 7 (17.5 %) | 21 (21.4 %) | |
Lymph node status | 0.388c | ||||
Yes | 63 (45.6 %) | 62 (46.3 %) | 17 (42.5 %) | 46 (46.9 %) | |
No | 75 (54.4 %) | 72 (53.7 %) | 23 (57.5 %) | 52 (53.1 %) | |
Distant metastases | 0.389c | ||||
Yes | 21 (15.2 %) | 21 (15.7 %) | 5 (12.5 %) | 16 (16.3 %) | |
No | 117 (84.8 %) | 113 (84.3 %) | 35 (87.5 %) | 82 (83.7 %) | |
Blood vessel invasion | 0.106c | ||||
Yes | 24 (17.4 %) | 23 (17.2 %) | 10 (25 %) | 14 (14.3 %) | |
No | 114 (82.6 %) | 111 (82.8 %) | 30 (75 %) | 84 (85.7 %) | |
Survival (n = 134) | |||||
5 years (median survival in months, 95 % CI, N° deaths) | ‐‐ | 59 (95 % CI --; 69 deaths) | -- (14 deaths) | 49 (95 % CI 32.9–65.1; 55 deaths) | 0.083e |
10 years (median survival in months, 95 % CI, N° deaths) | ‐‐ | 59 (95 % CI 27.3–90.7; 80 deaths) | -- (95 % CI --; 16 deaths) | 49 (95 % CI 32.9–65.1; 64 deaths) | 0.036e |
Median follow-up; range (months) | ‐‐ | 169; 166.75–171.25; 86 deaths | n/a; 20 deaths | n/a; 66 deaths | 0.111e |
Allred score (8-oxodG) | n/a | ||||
0 | 40 (29 %) | 37 (27.6 %) | 40 (100 %) | 0 | |
3 | 6 (4.3 %) | 6 (4.5 %) | 0 | 6 (6.1 %) | |
4 | 13 (9.4 %) | 13 (9.7 %) | 0 | 13 (13.3 %) | |
5 | 13 (9.4 %) | 13 (9.7 %) | 0 | 13 (13.3 %) | |
6 | 24 (17.4 %) | 24 (17.9 %) | 0 | 24 (24.5 %) | |
7 | 22 (15.9 %) | 22 (16.4 %) | 0 | 22 (22.4 %) | |
8 | 20 (14.5 %) | 19 (14.2 %) | 0 | 20 (20.4 %) |