Table 4 Univariate log-rank test of prognostic covariates in 130 patients with oral cavity squamous cell carcinoma regarding disease-free and overall survival
From: Serum markers of CYFRA 21-1 and C-reactive proteins in oral squamous cell carcinoma
DFS, P value | OS, P value | |
|---|---|---|
[HR (95 % CI)] | [HR (95 % CI)] | |
Age (years) | ||
<50 | 0.251 | 0.885 |
≥50 | 0.678 (0.349–1.316) | 0.938 (0.395–2.228) |
Sex | ||
Female | 0.776 | 0.164 |
Male | 1.163 (0.411–3.297) | 0.490 (0.179–1.337) |
Nodal status | ||
(−) metastasis, (−) ECS | 0.001 | 0.008 |
(+) metastasis, (−) ECS | 1.193 (0.384–3.705) | 1.858 (0.463–7.447) |
(+) metastasis, (+) ECS | 3.586 (1.733–7.420) | 4.618 (1.729–12.338) |
Differentiation | ||
Well/moderate | 0.027 | 0.041 |
Poor | 2.437 (1.105–5.372) | 2.868 (1.043–7.886) |
Pathologic tumor status | ||
Earlya | 0.023 | 0.096 |
Advancedb | 2.172 (1.111–4.247) | 2.084 (0.877–4.949) |
CRP | ||
<5 mg/mL | 0.016 | 0.027 |
≥5 mg/mL | 2.274 (1.163–4.448) | 2.636 (1.118–6.217) |
Cyfra 21-1 | ||
<3.3 ng/mL | 0.135 | 0.667 |
≥3.3 ng/mL | 1.885 (0.821–4.328) | 0.726 (0.169–3.120) |
Tumor depth | ||
<10 mm | 0.030 | 0.052 |
≥10 mm | 2.207 (1.080–4.510) | 2.560 (0.991–6.613) |
Cyfra 21-1 and CRP | 0.019 | 0.235 |
Cyfra 21-1 < 3.3 ng/mL, CRP < 5 mg/L | 1 | 1 |
Cyfra 21-1 ≥ 3.3 ng/mL, CRP < 5 mg/L | 0.575 (0.077–4.300) | 0.000 (0.000) |
Cyfra 21-1 < 3.3 ng/mL, CRP ≥ 5 mg/L | 1.683 (0.761–3.722) | 2.578 (1.036–6.414) |
Cyfra 21-1 ≥ 3.3 ng/mL, CRP ≥ 5 mg/L | 4.065 (1.610–10.261) | 1.928 (0.426–8.726) |