Table 3 The associations between preoperative CRP, CYFRA 21-1, and clinicopathologic parameters (N = 130)
From: Serum markers of CYFRA 21-1 and C-reactive proteins in oral squamous cell carcinoma
CRP (−), CYFRA 21-1 (−) | CRP (−),CYFRA 21-1 (+) | CRP (+),CYFRA 21-1 (−) | CRP (+),CYFRA 21-1 (+) | ||
|---|---|---|---|---|---|
(n (%)) | (n (%)) | (n (%)) | (n (%)) | P value | |
Tumor stage | |||||
Earlya (n = 45) | 33 (73.3) | 7 (15.6) | 5 (11.1) | 0 (0.0) | 0.009 e |
Advancedb (n = 85) | 52 (61.2) | 1 (1.2) | 22 (25.9) | 10 (11.8) | |
Pathologic N stage | |||||
N0 (n = 68) | 47 (69.1) | 7 (10.3) | 12 (17.6) | 2 (2.9) | 0.012 e |
N1 (n = 25) | 18 (72.0) | 0 (0.0) | 7 (28.0) | 0 (0.0) | |
N2 (n = 37) | 20 (54.1) | 1 (2.7) | 8 (21.6) | 8 (21.6) | |
Nodal status | |||||
(−) metastasis, (−) ECS (n = 68) | 47 (69.1) | 7 (10.3) | 12 (17.6) | 2 (2.9) | 0.006 e |
(+) metastasis, (−) ECS (n = 23) | 18 (78.3) | 0 (0.0) | 5 (21.7) | 0 (0.0) | |
(+) metastasis, (+) ECS (n = 39) | 20 (51.3) | 1 (2.6) | 10 (25.6) | 8 (20.5) | |
Differentiation | |||||
Well (n = 32) | 20 (62.5) | 1 (3.1) | 9 (28.1) | 2 (6.2) | 0.734 |
Moderate (n = 80) | 55 (68.8) | 6 (7.5) | 13 (16.2) | 6 (7.5) | |
Poor (n = 18) | 10 (55.6) | 1 (5.6) | 5 (27.8) | 2 (11.1) | |
Pathologic tumor status | |||||
Earlyc (n = 74) | 56 (75.7) | 8 (10.8) | 10 (13.5) | 0 (0.0) | <0.001 e |
Advancedd (n = 56) | 29 (51.8) | 0 (0.0) | 17 (30.4) | 10 (17.9) | |
Skin invasion | |||||
No (n = 117) | 80 (68.4) | 8 (6.8) | 22 (18.8) | 7 (6.0) | 0.006 e |
Yes (n = 13) | 5 (38.5) | 0 (0.0) | 5 (38.5) | 3 (23.1) | |
Bone invasion | |||||
No (n = 105) | 75 (71.4) | 8 (7.6) | 16 (15.2) | 6 (5.7) | 0.001 e |
Yes (n = 25) | 10 (40.0) | 0 (0.0) | 11 (44.0) | 4 (16.0) | |
Tumor depth ≥10 mm | |||||
No (n = 60) | 47 (78.3) | 6 (10.0) | 7 (11.7) | 0 (0.0) | <0.001 e |
Yes (n = 70) | 38 (54.3) | 2 (2.9) | 20 (28.6) | 10 (14.3) | |