From: Prolactin-producing pituitary adenoma with atypical spindle cell morphology: a case report
Staining | Case presentation | Pituitary adenoma | Pituicytoma | Paraganglioma | Spindle cell oncocytoma | Meningioma | Granular cell tumor |
---|---|---|---|---|---|---|---|
Histology | See text and Fig. 2 | Monotonous arrays of chromophobic cells in diffuse, papillary, or sinusoidal proliferation | Variably lobulated sheets of cells with copious cytoplasm and round, uniform nuclei with small nucleoli | Nested pattern (Zellballen configuration) and rimmed by sustentacular cells | Eosinophilic spindle-shaped or polygonal cells with granular cytoplasm (abundant mitochondria) | Spindle or polygonal cells with large oval nuclei and indistinct cell borders | Abundant granular eosinophilic cytoplasm with round monomorphic nuclei |
Pituitary hormones | ± | ± | − | − | − | − | − |
Cytokeratin | − | ± | − | − | − | 5 % | − |
EMA | − | >50 % | − | − | + | + | − |
S-100 protein | − | − | + | + | + | 20 % | + |
Vimentin | − | − | − | ± | + | + | + |
GFAP | − | − | + | ± | − | − | ± |
Synaptophysin | + | + | − | + | − | − | − |
Chromogranin-A | + | 90 % | − | 95 % | − | − | − |