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Table 1 Histology and immunostaining in differential diagnosis of tumors

From: Prolactin-producing pituitary adenoma with atypical spindle cell morphology: a case report

Staining Case presentation Pituitary adenoma Pituicytoma Paraganglioma Spindle cell oncocytoma Meningioma Granular cell tumor
Histology See text and Fig. 2 Monotonous arrays of chromophobic cells in diffuse, papillary, or sinusoidal proliferation Variably lobulated sheets of cells with copious cytoplasm and round, uniform nuclei with small nucleoli Nested pattern (Zellballen configuration) and rimmed by sustentacular cells Eosinophilic spindle-shaped or polygonal cells with granular cytoplasm (abundant mitochondria) Spindle or polygonal cells with large oval nuclei and indistinct cell borders Abundant granular eosinophilic cytoplasm with round monomorphic nuclei
Pituitary hormones ± ±
Cytokeratin ± 5 %
EMA >50 % + +
S-100 protein + + + 20 % +
Vimentin ± + + +
GFAP + ± ±
Synaptophysin + + +
Chromogranin-A + 90 % 95 %
  1. EMA epithelial membrane antigen, GFAP glial fibrillary acidic protein