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Table 3 Top ten of differentially expressed genes in the NSLN positive group

From: Molecular biomarkers screened by next-generation RNA sequencing for non-sentinel lymph node status prediction in breast cancer patients with metastatic sentinel lymph nodes

Gene

NSLN negative

NSLN positive

Log2(FC)

FDR

Description

Up-regulated genes

KLK11

0.93

185.48

7.64

0.00015

Kallikrein-related peptidase 11

SCGB3A1

8.06

1231.39

7.26

4.89E-05

Secretoglobin, family 3A, member 1

CLEC3A

0.98

143.59

7.19

2.96E-06

C-type lectin domain family 3, member A

CYP2A6

0.45

63.31

7.12

0.00029

Cytochrome P450, family 2, subfamily A, polypeptide 6

KLK10

0.17

19.11

6.80

0.0034

Kallikrein-related peptidase 10

KLK12

0.89

94.90

6.73

0.0011

Kallikrein-related peptidase 12

KLK13

0.57

49.98

6.45

7.42E-05

Kallikrein-related peptidase 13

CYP2A7

0.33

26.37

6.32

0.0052

Cytochrome P450, family 2, subfamily A, polypeptide 7

OBP2B

0.43

33.39

6.29

0.0391

Odorant binding protein 2B

KCNC2

0.32

21.60

6.09

0.0040

Potassium voltage-gated channel, Shaw-related subfamily, member 2

Down-regulated genes

KRT20

17.19

0.07

−7.95

0.00019

Keratin 20

KRT4

6.42

0.05

−7.14

0.048

Keratin 4

VPREB1

25.93

0.19

−7.10

0.012

Pre-B lymphocyte 1

RBP2

31.24

0.58

−5.75

0.0014

Retinol binding protein 2, cellular

ALDOB

4.64

0.09

−5.66

0.011

Aldolase B, fructose-bisphosphate

BIRC7

7.80

0.16

−5.57

0.017

Baculoviral IAP repeat containing 7

FIBCD1

7.75

0.19

−5.38

0.00091

Fibrinogen C domain containing 1

MUC13

8.85

0.23

−5.24

0.0022

Mucin 13, cell surface associated

FCAMR

50.50

1.38

−5.19

4.97E-12

Fc receptor, IgA, IgM, high affinity

DHRS2

19.04

0.55

−5.10

0.0085

Dehydrogenase/reductase (SDR family) member 2

  1. FC fold change of (NLSN positive/negative)