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Table 3 Top ten of differentially expressed genes in the NSLN positive group

From: Molecular biomarkers screened by next-generation RNA sequencing for non-sentinel lymph node status prediction in breast cancer patients with metastatic sentinel lymph nodes

Gene NSLN negative NSLN positive Log2(FC) FDR Description
Up-regulated genes
KLK11 0.93 185.48 7.64 0.00015 Kallikrein-related peptidase 11
SCGB3A1 8.06 1231.39 7.26 4.89E-05 Secretoglobin, family 3A, member 1
CLEC3A 0.98 143.59 7.19 2.96E-06 C-type lectin domain family 3, member A
CYP2A6 0.45 63.31 7.12 0.00029 Cytochrome P450, family 2, subfamily A, polypeptide 6
KLK10 0.17 19.11 6.80 0.0034 Kallikrein-related peptidase 10
KLK12 0.89 94.90 6.73 0.0011 Kallikrein-related peptidase 12
KLK13 0.57 49.98 6.45 7.42E-05 Kallikrein-related peptidase 13
CYP2A7 0.33 26.37 6.32 0.0052 Cytochrome P450, family 2, subfamily A, polypeptide 7
OBP2B 0.43 33.39 6.29 0.0391 Odorant binding protein 2B
KCNC2 0.32 21.60 6.09 0.0040 Potassium voltage-gated channel, Shaw-related subfamily, member 2
Down-regulated genes
KRT20 17.19 0.07 −7.95 0.00019 Keratin 20
KRT4 6.42 0.05 −7.14 0.048 Keratin 4
VPREB1 25.93 0.19 −7.10 0.012 Pre-B lymphocyte 1
RBP2 31.24 0.58 −5.75 0.0014 Retinol binding protein 2, cellular
ALDOB 4.64 0.09 −5.66 0.011 Aldolase B, fructose-bisphosphate
BIRC7 7.80 0.16 −5.57 0.017 Baculoviral IAP repeat containing 7
FIBCD1 7.75 0.19 −5.38 0.00091 Fibrinogen C domain containing 1
MUC13 8.85 0.23 −5.24 0.0022 Mucin 13, cell surface associated
FCAMR 50.50 1.38 −5.19 4.97E-12 Fc receptor, IgA, IgM, high affinity
DHRS2 19.04 0.55 −5.10 0.0085 Dehydrogenase/reductase (SDR family) member 2
  1. FC fold change of (NLSN positive/negative)