|
Parameters
|
Overall survival
|
Cancer-specific survival
|
|---|
| |
Univariate analysis
|
Multivariable analysis
|
Univariate analysis
|
Multivariable analysis
|
|---|
|
HRc (95 % CId)
|
P value
|
HRc (95 % CId)
|
P value
|
HRc (95 % CId)
|
P value
|
HRc (95 % CId)
|
P value
|
|---|
|
Age (years)
|
1.157 (0.801 – 1.671)
|
0.437
|
1.032 (0.607 – 1.754)
|
0.909
|
1.157(0.801 – 1.670)
|
0.438
|
1.032 (0.607 – 1.757)
|
0.906
|
|
≥65 vs <65 (151/180)
|
|
Gender
|
1.347 (0.926 – 1.960)
|
0.119
|
1.348 (0.795 – 1.356)
|
0.227
|
1.336 (0.918 – 1.942)
|
0.130
|
1.341 (0.827 – 2.176)
|
0.235
|
|
Male vs Female (183/148)
|
|
Location
|
1.828 (1.242 – 2.681)
|
0.002*
|
1.536 (0.939 – 2.513)
|
0.087
|
1.842 (1.253 – 2.703)
|
0.002*
|
1.548 (0.946 – 2.532)
|
0.082
|
|
Right vs Left (80/251)
|
|
Tumor size
|
1.625 (1.120 – 2.359)
|
0.011
|
1.557 (0.951 – 2.548)
|
0.078
|
1.617 (1.114 – 2.345)
|
0.011*
|
1.544 (0.944 – 2.527)
|
0.084
|
|
≥5 cm vs <5 cm (148/181)
|
|
Tumor depth
|
1.639 (0.799 – 3.363)
|
0.178
|
0.935 (0.347 – 2.515)
|
0.894
|
1.651 (0.805 – 3.388)
|
0.171
|
0.937 (0.348 – 2.520)
|
0.897
|
|
T3 + T4 vs T1 + T2 (297/34)
|
|
Histology
|
2.171 (1.378 – 3.419)
|
0.001*
|
1.761 (0.969 – 3.201)
|
0.063
|
2.185 (1.387 – 3.442)
|
0.001*
|
1.767 (0.972 – 3.210)
|
0.062
|
|
PD vs MD + WDa (45/277)
|
|
Vascular invasion
|
2.307 (1.565 – 3.399)
|
<0.001*
|
1.784 (1.091 – 2.915)
|
0.021*
|
2.291 (1.555 – 3.376)
|
<0.001*
|
1.777 (1.087 – 2.904)
|
0.022*
|
|
Yes vs No (142/184)
|
|
Perineural invasion
|
1.866 (1.286 – 2.765)
|
0.001*
|
1.822 (1.112 – 2.986)
|
0.017*
|
1.880 (1.282 – 2.757)
|
0.001*
|
1.820 (1.111 – 2.983)
|
0.017*
|
|
Yes vs No (142/183)
|
|
Pre-op CEAb (ng/ml)
|
1.925 (1.288 – 2.875)
|
0.001*
|
1.237 (0.697 – 2.195)
|
0.468
|
1.945 (1.301 – 2.908)
|
0.001*
|
1.253 (0.706 – 2.224)
|
0.441
|
|
≥5/ vs <5 (158/150)
|
|
Post-op CEAb (ng/ml)
|
3.253 (2.198 – 4.816)
|
<0.001*
|
2.053 (1.187 – 3.550)
|
0.010*
|
3.285 (2.218 – 4.864)
|
<0.001*
|
2.064 (1.193 – 3.571)
|
0.010*
|
|
≥5 vs <5 (81/234)
|
|
Pre-op albumin (g/dl)
|
1.480 (0.965 – 2.269)
|
0.072
|
1.237 (0.740 – 2.067)
|
0.417
|
1.474 (0.961 – 2.259)
|
0.075
|
1.226 (0.734 – 2.046)
|
0.437
|
|
<3.5 vs ≥3.5 (85/185)
|
|
Diabetes mellitus
|
1.331 (0.888 – 1.996)
|
0.166
|
1.103 (0.633 – 1.924)
|
0.729
|
1.325 (0.884 –1.987)
|
0.173
|
1.091 (0.626 – 1.903)
|
0.758
|
|
Yes vs No (80/251)
|
|
Cardiac disease
|
1.337 (0.926 – 1.931)
|
0.121
|
0.796 (0.464 – 1.366)
|
0.407
|
1.342 (0.929 – 1.938)
|
0.117
|
0.799 (0.465 – 1.372)
|
0.415
|
|
Yes vs No (137/194)
|
|
Renal disease
|
4.151 (2.164 – 7.963)
|
<0.001*
|
2.981 (1.089 – 8.157)
|
0.033*
|
4.165 (2.171 – 7.999)
|
<0.001*
|
2.979 (1.088 – 8.159)
|
0.034*
|
|
Yes vs No (13/318)
|
|
Chemotherapy
|
0.437 (0.257 – 0.742)
|
0.002*
|
1.061 (0.434 – 2.594)
|
0.897
|
0.435 (0.256 – 0.738)
|
0.002*
|
1.078 (0.440 – 2.639)
|
0.869
|
|
Yes vs No (31/299)
|
-
aPD Poorly differentiated, MD Moderately differentiated, WD Well differentiated, b CEA Carcinoembryonic antigen, cHR Hazard ratio,
-
dConfidence interval
- *Indicated P < 0.05
