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Table 4 Univariate and multivariable analysis of prognostic indicators on overall survival and cancer-specific survival for 331 stage III colorectal cancer patients

From: Different clinicopathologic features and favorable outcomes of patients with stage III left-sided colon cancer

Parameters Overall survival Cancer-specific survival
  Univariate analysis Multivariable analysis Univariate analysis Multivariable analysis
HRc (95 % CId) P value HRc (95 % CId) P value HRc (95 % CId) P value HRc (95 % CId) P value
Age (years) 1.157 (0.801 – 1.671) 0.437 1.032 (0.607 – 1.754) 0.909 1.157(0.801 – 1.670) 0.438 1.032 (0.607 – 1.757) 0.906
≥65 vs <65 (151/180)
Gender 1.347 (0.926 – 1.960) 0.119 1.348 (0.795 – 1.356) 0.227 1.336 (0.918 – 1.942) 0.130 1.341 (0.827 – 2.176) 0.235
Male vs Female (183/148)
Location 1.828 (1.242 – 2.681) 0.002* 1.536 (0.939 – 2.513) 0.087 1.842 (1.253 – 2.703) 0.002* 1.548 (0.946 – 2.532) 0.082
Right vs Left (80/251)
Tumor size 1.625 (1.120 – 2.359) 0.011 1.557 (0.951 – 2.548) 0.078 1.617 (1.114 – 2.345) 0.011* 1.544 (0.944 – 2.527) 0.084
≥5 cm vs <5 cm (148/181)
Tumor depth 1.639 (0.799 – 3.363) 0.178 0.935 (0.347 – 2.515) 0.894 1.651 (0.805 – 3.388) 0.171 0.937 (0.348 – 2.520) 0.897
T3 + T4 vs T1 + T2 (297/34)
Histology 2.171 (1.378 – 3.419) 0.001* 1.761 (0.969 – 3.201) 0.063 2.185 (1.387 – 3.442) 0.001* 1.767 (0.972 – 3.210) 0.062
PD vs MD + WDa (45/277)
Vascular invasion 2.307 (1.565 – 3.399) <0.001* 1.784 (1.091 – 2.915) 0.021* 2.291 (1.555 – 3.376) <0.001* 1.777 (1.087 – 2.904) 0.022*
Yes vs No (142/184)
Perineural invasion 1.866 (1.286 – 2.765) 0.001* 1.822 (1.112 – 2.986) 0.017* 1.880 (1.282 – 2.757) 0.001* 1.820 (1.111 – 2.983) 0.017*
Yes vs No (142/183)
Pre-op CEAb (ng/ml) 1.925 (1.288 – 2.875) 0.001* 1.237 (0.697 – 2.195) 0.468 1.945 (1.301 – 2.908) 0.001* 1.253 (0.706 – 2.224) 0.441
≥5/ vs <5 (158/150)
Post-op CEAb (ng/ml) 3.253 (2.198 – 4.816) <0.001* 2.053 (1.187 – 3.550) 0.010* 3.285 (2.218 – 4.864) <0.001* 2.064 (1.193 – 3.571) 0.010*
≥5 vs <5 (81/234)
Pre-op albumin (g/dl) 1.480 (0.965 – 2.269) 0.072 1.237 (0.740 – 2.067) 0.417 1.474 (0.961 – 2.259) 0.075 1.226 (0.734 – 2.046) 0.437
<3.5 vs ≥3.5 (85/185)
Diabetes mellitus 1.331 (0.888 – 1.996) 0.166 1.103 (0.633 – 1.924) 0.729 1.325 (0.884 –1.987) 0.173 1.091 (0.626 – 1.903) 0.758
Yes vs No (80/251)
Cardiac disease 1.337 (0.926 – 1.931) 0.121 0.796 (0.464 – 1.366) 0.407 1.342 (0.929 – 1.938) 0.117 0.799 (0.465 – 1.372) 0.415
Yes vs No (137/194)
Renal disease 4.151 (2.164 – 7.963) <0.001* 2.981 (1.089 – 8.157) 0.033* 4.165 (2.171 – 7.999) <0.001* 2.979 (1.088 – 8.159) 0.034*
Yes vs No (13/318)
Chemotherapy 0.437 (0.257 – 0.742) 0.002* 1.061 (0.434 – 2.594) 0.897 0.435 (0.256 – 0.738) 0.002* 1.078 (0.440 – 2.639) 0.869
Yes vs No (31/299)
  1. aPD Poorly differentiated, MD Moderately differentiated, WD Well differentiated, b CEA Carcinoembryonic antigen, cHR Hazard ratio,
  2. dConfidence interval
  3. *Indicated P < 0.05