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Table 4 Univariate and multivariable analysis of prognostic indicators on overall survival and cancer-specific survival for 331 stage III colorectal cancer patients

From: Different clinicopathologic features and favorable outcomes of patients with stage III left-sided colon cancer

Parameters

Overall survival

Cancer-specific survival

 

Univariate analysis

Multivariable analysis

Univariate analysis

Multivariable analysis

HRc (95 % CId)

P value

HRc (95 % CId)

P value

HRc (95 % CId)

P value

HRc (95 % CId)

P value

Age (years)

1.157 (0.801 – 1.671)

0.437

1.032 (0.607 – 1.754)

0.909

1.157(0.801 – 1.670)

0.438

1.032 (0.607 – 1.757)

0.906

≥65 vs <65 (151/180)

Gender

1.347 (0.926 – 1.960)

0.119

1.348 (0.795 – 1.356)

0.227

1.336 (0.918 – 1.942)

0.130

1.341 (0.827 – 2.176)

0.235

Male vs Female (183/148)

Location

1.828 (1.242 – 2.681)

0.002*

1.536 (0.939 – 2.513)

0.087

1.842 (1.253 – 2.703)

0.002*

1.548 (0.946 – 2.532)

0.082

Right vs Left (80/251)

Tumor size

1.625 (1.120 – 2.359)

0.011

1.557 (0.951 – 2.548)

0.078

1.617 (1.114 – 2.345)

0.011*

1.544 (0.944 – 2.527)

0.084

≥5 cm vs <5 cm (148/181)

Tumor depth

1.639 (0.799 – 3.363)

0.178

0.935 (0.347 – 2.515)

0.894

1.651 (0.805 – 3.388)

0.171

0.937 (0.348 – 2.520)

0.897

T3 + T4 vs T1 + T2 (297/34)

Histology

2.171 (1.378 – 3.419)

0.001*

1.761 (0.969 – 3.201)

0.063

2.185 (1.387 – 3.442)

0.001*

1.767 (0.972 – 3.210)

0.062

PD vs MD + WDa (45/277)

Vascular invasion

2.307 (1.565 – 3.399)

<0.001*

1.784 (1.091 – 2.915)

0.021*

2.291 (1.555 – 3.376)

<0.001*

1.777 (1.087 – 2.904)

0.022*

Yes vs No (142/184)

Perineural invasion

1.866 (1.286 – 2.765)

0.001*

1.822 (1.112 – 2.986)

0.017*

1.880 (1.282 – 2.757)

0.001*

1.820 (1.111 – 2.983)

0.017*

Yes vs No (142/183)

Pre-op CEAb (ng/ml)

1.925 (1.288 – 2.875)

0.001*

1.237 (0.697 – 2.195)

0.468

1.945 (1.301 – 2.908)

0.001*

1.253 (0.706 – 2.224)

0.441

≥5/ vs <5 (158/150)

Post-op CEAb (ng/ml)

3.253 (2.198 – 4.816)

<0.001*

2.053 (1.187 – 3.550)

0.010*

3.285 (2.218 – 4.864)

<0.001*

2.064 (1.193 – 3.571)

0.010*

≥5 vs <5 (81/234)

Pre-op albumin (g/dl)

1.480 (0.965 – 2.269)

0.072

1.237 (0.740 – 2.067)

0.417

1.474 (0.961 – 2.259)

0.075

1.226 (0.734 – 2.046)

0.437

<3.5 vs ≥3.5 (85/185)

Diabetes mellitus

1.331 (0.888 – 1.996)

0.166

1.103 (0.633 – 1.924)

0.729

1.325 (0.884 –1.987)

0.173

1.091 (0.626 – 1.903)

0.758

Yes vs No (80/251)

Cardiac disease

1.337 (0.926 – 1.931)

0.121

0.796 (0.464 – 1.366)

0.407

1.342 (0.929 – 1.938)

0.117

0.799 (0.465 – 1.372)

0.415

Yes vs No (137/194)

Renal disease

4.151 (2.164 – 7.963)

<0.001*

2.981 (1.089 – 8.157)

0.033*

4.165 (2.171 – 7.999)

<0.001*

2.979 (1.088 – 8.159)

0.034*

Yes vs No (13/318)

Chemotherapy

0.437 (0.257 – 0.742)

0.002*

1.061 (0.434 – 2.594)

0.897

0.435 (0.256 – 0.738)

0.002*

1.078 (0.440 – 2.639)

0.869

Yes vs No (31/299)

  1. aPD Poorly differentiated, MD Moderately differentiated, WD Well differentiated, b CEA Carcinoembryonic antigen, cHR Hazard ratio,
  2. dConfidence interval
  3. *Indicated P < 0.05