|
Characteristic
|
Stage I
|
Stage II
|
Stage III
|
Stage IV
|
|---|
| |
Right-sided colon (%)
|
Left-sided colon (%)
|
P value
|
Right-sided colon (%)
|
Left-sided colon (%)
|
P value
|
Right-sided colon (%)
|
Left-sided colon (%)
|
P value
|
Right-sided colon (%)
|
Left-sided colon (%)
|
P value
|
|---|
|
N = 28 (14.6 %)
|
N = 164 (85.3 %)
|
N = 101 (26.1 %)
|
N = 286 (73.9 %)
|
N = 80 (24.2 %)
|
N = 251 (75.8 %)
|
N = 40 (21.4 %)
|
N = 145 (78.4 %)
|
|---|
|
Age (years, mean ± SD)
|
67.36 ± 10.05
|
65.04 ± 13.20
|
0.289
|
65.90 ± 13.67
|
65.30 ± 12.15
|
0.678
|
61.99 ± 14.86
|
61.90 ± 13.21
|
0.959
|
66.70 ± 11.57
|
62.85 ± 12.77
|
0.087
|
|
Gender
| | |
0.603
| | |
0.244
| | |
0.751
| | |
0.011*
|
|
Female
|
12 (42.9)
|
79 (48.2)
|
52 (47.3)
|
128 (40.9)
|
37 (46.3)
|
111 (44.2)
|
23 (57.5)
|
51 (35.2)
|
|
Male
|
16 (57.1)
|
85 (51.8)
|
58 (52.7)
|
185 (59.1)
|
43 (53.8)
|
140 (55.8)
|
17 (42.5)
|
94 (64.8)
|
|
Tumor size
| | |
1.000
| | |
0.060
| | |
0.070
| | |
0.921
|
|
< 5 cm
|
24 (85.7)
|
139 (85.8)
|
42 (41.6)
|
150 (52.4)
|
37 (46.3)
|
144 (57.8)
|
18 (46.2)
|
62 (45.3)
|
|
≥ 5 cm
|
4 (14.3)
|
23 (14.2)
|
59 (58.4)
|
136 (47.6)
|
43 (53.8)
|
105 (42.2)
|
21 (53.8)
|
75 (54.7)
|
|
Histology
| | |
0.195
| | |
0.002*
| | |
0.036*
| | |
0.517
|
|
Well
|
10 (35.7)
|
32 (20.3)
|
6 (6.1)
|
11 (3.9)
|
3 (3.9)
|
5 (2.0)
|
1 (2.6)
|
3 (2.2)
|
|
Moderately
|
17 (60.7)
|
120 (75.9)
|
76 (76.8)
|
255 (90.1)
|
57 (74.0)
|
212 (86.5)
|
31 (79.5)
|
117 (86.7)
|
|
Poorly
|
1 (3.6)
|
6 (3.8)
|
17 (17.2)
|
17 (6.0)
|
17 (22.1)
|
28 (11.4)
|
7 (17.9)
|
15 (11.1)
|
|
Tumor depth
| | |
0.872
| | |
0.197
| | |
0.457
| | |
0.858
|
|
T1
|
10 (35.7)
|
56 (34.1)
|
0 (0.0)
|
0 (0.0)
|
2 (2.5)
|
2 (0.8)
|
0 (0.0)
|
1 (0.7)
|
|
T2
|
18 (64.3)
|
108 (65.9)
|
0 (0.0)
|
0 (0.0)
|
5 (6.3)
|
25 (10.0)
|
1 (2.6)
|
6 (4.3)
|
|
T3
|
0 (0.0)
|
0 (0.0)
|
101 (100.0)
|
279 (97.6)
|
67 (83.8)
|
209 (83.3)
|
31 (79.5)
|
103 (74.1)
|
|
T4
|
0 (0.0)
|
0 (0.0)
|
0 (0.0)
|
7 (2.4)
|
6 (7.5)
|
15 (6.0)
|
7 (17.9)
|
29 (20.9)
|
|
Lymph Node metastasis
| | | | | |
0.158
| |
0.813
|
|
N0
|
0 (0.0)
|
0 (0.0)
|
0 (0.0)
|
0 (0.0)
|
0 (0.0)
|
0 (0.0)
|
13 (33.3)
|
41 (30.1)
|
|
N1
|
0 (0.0)
|
0 (0.0)
|
0 (0.0)
|
0 (0.0)
|
49 (61.3)
|
175 (69.7)
|
13 (33.3)
|
42 (30.9)
|
|
N2
|
0 (0.0)
|
0 (0.0)
|
0 (0.0)
|
0 (0.0)
|
31 (38.8)
|
76 (30.3)
|
13 (33.3)
|
53 (39.0)
|
|
Vascular invasion
| | |
0.695
| | |
0.133
| | |
0.110
| | |
0.510
|
|
No
|
27 (96.4)
|
146 (92.4)
|
83 (82.2)
|
211 (74.8)
|
39 (48.8)
|
145 (58.9)
|
14 (38.9)
|
59 (45.0)
|
|
Yes
|
1 (3.6)
|
12 (7.6)
|
18 (17.8)
|
71 (25.2)
|
41 (51.2)
|
101 (41.1)
|
22 (61.1)
|
72 (55.0)
|
|
Perineural invasion
| | |
0.473
| | |
0.861
| | |
0.512
| | |
0.790
|
|
No
|
27 (96.4)
|
143 (90.5)
|
67 (66.3)
|
185 (65.4)
|
47 (59.5)
|
136 (55.3)
|
16 (42.1)
|
52 (39.7)
|
|
Yes
|
1 (3.6)
|
15 (9.5)
|
34 (33.7)
|
98 (34.6)
|
32 (40.5)
|
110 (44.7)
|
22 (57.9)
|
79 (60.3)
|
|
Pre-op serum CEAa level
| | |
0.560
| | |
0.237
| | |
0.043*
| | |
0.410
|
|
< 5 ng/ml
|
22 (81.5)
|
127 (85.8)
|
62 (62.6)
|
150 (55.8)
|
28 (38.4)
|
122 (51.9)
|
9 (25.0)
|
25 (18.8)
|
|
≥ 5 ng/ml
|
5 (18.5)
|
21 (14.2)
|
37 (37.4)
|
119 (44.2)
|
45 (61.6)
|
113 (48.1)
|
27 (75.0)
|
108 (81.2)
| |
|
Post-op serum CEAa level
| | |
0.697
| | |
0.158
| | |
0.025*
| | |
0.764
|
|
< 5 ng/ml
|
24 (96.0)
|
140 (92.1)
|
75 (79.8)
|
232 (85.9)
|
49 (64.5)
|
185 (77.4)
|
10 (27.0)
|
37 (29.6)
|
|
≥ 5 ng/ml
|
1 (4.0)
|
12 (7.9)
|
19 (20.2)
|
38 (14.1)
|
27 (35.5)
|
54 (22.6)
|
27 (73.0)
|
88 (70.4)
|
|
Pre-op serum Albumin level (g/dl)
|
3.72 ± 0.37
|
3.76 ± 0.39
|
0.664
|
3.46 ± 0.47
|
3.58 ± 0.46
|
0.030
|
3.68 ± 0.37
|
3.69 ± 0.40
|
0.887
|
3.48 ± 0.45
|
3.46 ± 0.50
|
0.885
|
|
Diabetes mellitus
| | |
0.307
| |
0.841
| |
0.920
| |
0.844
|
|
Yes
|
9 (32.1)
|
38 (23.2)
|
24 (23.8)
|
69 (24.1)
|
19 (23.8)
|
61 (24.3)
|
8 (20.0)
|
27 (18.6)
|
|
No
|
19 (67.9)
|
126 (76.8)
|
77 (76.2)
|
217 (75.9)
|
62 (76.2)
|
190 (75.7)
|
32 (80.0)
|
118 (81.4)
|
|
Chemotherapy
| | | | | |
0.030*
| | |
0.852
| | |
0.817
|
|
Yes
|
53 (52.5)
|
185 (64.7)
|
72 (91.1)
|
227 (90.4)
|
33(82.6)
|
121 (84.0)
|
|
No
|
48 (47.5)
|
101 (35.3)
|
7 (8.9)
|
24 (9.6)
|
7 (17.5)
|
23 (16.0)
|
|
Cardiac disease
| | |
0.257
| | |
0.365
| | |
0.772
| | |
0.976
|
|
Yes
|
15 (53.6)
|
69 (42.1)
|
41 (40.6)
|
131 (45.8)
|
32 (40.0)
|
105 (41.8)
|
15 (37.5)
|
54 (37.2)
|
|
No
|
13 (46.4)
|
95 (57.9)
|
60 (59.4)
|
156 (54.2)
|
48 (60.0)
|
146 (58.2)
|
25 (62.5)
|
91 (62.8)
|
|
Renal disease
| | |
0.127*
| | |
0.693
| | |
0.450
| | |
1.000
|
|
Yes
|
3 (10.7)
|
6 (3.7)
|
6 (5.9)
|
14 (4.9)
|
2 (2.5)
|
11 (4.4)
|
2 (5.0)
|
8 (5.5)
|
|
No
|
25 (89.3)
|
158 (96.3)
|
95 (94.1)
|
272 (95.1)
|
78 (97.5)
|
240 (95.6)
|
38 (95.0)
|
137 (94.5)
|
|
BMIb
|
23.94 ± 3.88
|
23.70 ± 3.73
|
0.748
|
23.80 ± 4.39
|
23.73 ± 3.73
|
0.092
|
23.71 ± 4.13
|
23.95 ± 3.44
|
0.616
|
22.23 ± 4.31
|
22.77 ± 3.50
|
0.418
|
-
aCEA Carcinoembryonic antigen, bBMI Body mass index, *Indicated P < 0.05
