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Table 3 Predictors of survival after resection of intrahepatic cholangiocarcinoma (n = 153)

From: Predictors and patterns of recurrence after curative liver resection in intrahepatic cholangiocarcinoma, for application of postoperative radiotherapy: a retrospective study

Characteristic

Univariate

Multivariate

HR (95 % CI)

p value

HR (95 % CI)

p value

Sex

0.873 (0.568–1.344)

0.538

  

Age

1.011 (0.988–1.036)

0.347

  

PT–INR

24.618 (3.449–161.735)

0.001

  

Type of resection

 

0.137

  

 Wedge resection

0.450 (0.062–3.258)

0.429

  

 Segmentectomy

0.949 (0.432–2.087)

0.897

  

 Multiple segmentectomy

0.655 (0.343–1.252)

0.201

  

 Hemihepatectomy

1

   

 Extended hemihepatectomy

1.677 (0.969–2.903)

0.065

  

Tumor subtype

0.367 (0.207–0.654)

0.001

0.536 (0.297–0.968)

0.039

Histology

0.680 (0.314–1.475)

0.329

  

Tumor size ≥4.0 cm

3.162 (1.928–5.184)

<0.001

2.539 (1.512–4.264)

<0.001

Multiple tumor

2.475 (1.585–3.864)

<0.001

1.782 (1.122–2.828)

0.014

LVI

2.299 (1.520–3.475)

<0.001

1.684 (1.107–2.564)

0.015

PNI

1.869 (1.181–2.957)

0.008

  

LN metastasis

3.902 (2.499–6.091)

<0.001

3.567 (2.240–5.680)

<0.001

Resection margin

0.991 (0.974–1.008)

0.294

  

HBV

1.165 (0.695–1.955)

0.562

  

HCV

1.226 (0.496–3.026)

0.659

  
  1. LVI lymphovascular invasion, PNI perineural invasion, HBV hepatitis B virus, HCV hepatitis C virus, PT–INR prothrombin time–international normalized ratio