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Table 3 Predictors of survival after resection of intrahepatic cholangiocarcinoma (n = 153)

From: Predictors and patterns of recurrence after curative liver resection in intrahepatic cholangiocarcinoma, for application of postoperative radiotherapy: a retrospective study

Characteristic Univariate Multivariate
HR (95 % CI) p value HR (95 % CI) p value
Sex 0.873 (0.568–1.344) 0.538   
Age 1.011 (0.988–1.036) 0.347   
PT–INR 24.618 (3.449–161.735) 0.001   
Type of resection   0.137   
 Wedge resection 0.450 (0.062–3.258) 0.429   
 Segmentectomy 0.949 (0.432–2.087) 0.897   
 Multiple segmentectomy 0.655 (0.343–1.252) 0.201   
 Hemihepatectomy 1    
 Extended hemihepatectomy 1.677 (0.969–2.903) 0.065   
Tumor subtype 0.367 (0.207–0.654) 0.001 0.536 (0.297–0.968) 0.039
Histology 0.680 (0.314–1.475) 0.329   
Tumor size ≥4.0 cm 3.162 (1.928–5.184) <0.001 2.539 (1.512–4.264) <0.001
Multiple tumor 2.475 (1.585–3.864) <0.001 1.782 (1.122–2.828) 0.014
LVI 2.299 (1.520–3.475) <0.001 1.684 (1.107–2.564) 0.015
PNI 1.869 (1.181–2.957) 0.008   
LN metastasis 3.902 (2.499–6.091) <0.001 3.567 (2.240–5.680) <0.001
Resection margin 0.991 (0.974–1.008) 0.294   
HBV 1.165 (0.695–1.955) 0.562   
HCV 1.226 (0.496–3.026) 0.659   
  1. LVI lymphovascular invasion, PNI perineural invasion, HBV hepatitis B virus, HCV hepatitis C virus, PT–INR prothrombin time–international normalized ratio