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Table 2 Predictors of recurrence after resection of intrahepatic cholangiocarcinoma (n = 153)

From: Predictors and patterns of recurrence after curative liver resection in intrahepatic cholangiocarcinoma, for application of postoperative radiotherapy: a retrospective study

Characteristic

Univariate

Multivariate

HR (95 % CI)

p value

HR (95 % CI)

p value

Sex

1.046 (0.688–1.589)

0.835

  

Age

1.011 (0.988–1.034)

0.360

  

PT–INR

7.894 (1.041–59.841)

0.046

  

Type of resection

 

0.483

  

 Wedge resection

0.917 (0.223–9.767)

0.904

  

 Segmentectomy

1.264 (0.601–2.661)

0.537

  

 Multiple segmentectomy

0.729 (0.399–1.335)

0.306

  

 Hemihepatectomy

1

   

 Extended hemihepatectomy

1.419 (0.799–2.518)

0.232

  

Tumor subtype

0.386 (0.221–0.676)

0.001

  

Histology

0.394 (0.144–1.075)

0.069

  

Tumor size ≥4.0 cm

2.932 (1.830–4.696)

<0.001

2.522 (1.556–4.088)

<0.001

Multiple tumors

2.020 (1.279–3.191)

0.003

1.815 (1.125–2.927)

0.015

LVI

1.866 (1.232–2.826)

0.003

  

PNI

1.825 (1.156–2.880)

0.010

  

LN metastasis

2.277 (1.424–3.642)

0.001

2.004 (1.221–3.289)

0.006

Resection margin

0.988 (0.972–1.044)

0.144

  

HBV

1.135 (0.685–1.881)

0.623

  

HCV

1.550 (0.624–3.849)

0.345

  
  1. LVI lymphovascular invasion, PNI perineural invasion, HBV hepatitis B virus, HCV hepatitis C virus, PT–INR prothrombin time–international normalized ratio