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Table 2 Predictors of recurrence after resection of intrahepatic cholangiocarcinoma (n = 153)

From: Predictors and patterns of recurrence after curative liver resection in intrahepatic cholangiocarcinoma, for application of postoperative radiotherapy: a retrospective study

Characteristic Univariate Multivariate
HR (95 % CI) p value HR (95 % CI) p value
Sex 1.046 (0.688–1.589) 0.835   
Age 1.011 (0.988–1.034) 0.360   
PT–INR 7.894 (1.041–59.841) 0.046   
Type of resection   0.483   
 Wedge resection 0.917 (0.223–9.767) 0.904   
 Segmentectomy 1.264 (0.601–2.661) 0.537   
 Multiple segmentectomy 0.729 (0.399–1.335) 0.306   
 Hemihepatectomy 1    
 Extended hemihepatectomy 1.419 (0.799–2.518) 0.232   
Tumor subtype 0.386 (0.221–0.676) 0.001   
Histology 0.394 (0.144–1.075) 0.069   
Tumor size ≥4.0 cm 2.932 (1.830–4.696) <0.001 2.522 (1.556–4.088) <0.001
Multiple tumors 2.020 (1.279–3.191) 0.003 1.815 (1.125–2.927) 0.015
LVI 1.866 (1.232–2.826) 0.003   
PNI 1.825 (1.156–2.880) 0.010   
LN metastasis 2.277 (1.424–3.642) 0.001 2.004 (1.221–3.289) 0.006
Resection margin 0.988 (0.972–1.044) 0.144   
HBV 1.135 (0.685–1.881) 0.623   
HCV 1.550 (0.624–3.849) 0.345   
  1. LVI lymphovascular invasion, PNI perineural invasion, HBV hepatitis B virus, HCV hepatitis C virus, PT–INR prothrombin time–international normalized ratio