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Table 3 Predictive factors for local control

From: Feasibility and efficacy of helical tomotherapy in cirrhotic patients with unresectable hepatocellular carcinoma

 

Univariate analysis

 

Multivariate analysis

 

Parameters

Hazard ratio (95 % CI)

P value

Hazard ratio (95 % CI)

P value

Age (≤67/>67) years

1.13 (0.49–2.78)

0.772

1.01 (0.97–1.07)

0.762

Gender (male/female)

0.75 (0.31–1.76)

0.519

1.33 (0.46–3.95)

0.585

ECOG score (0–1/2)

1.13 (0.48–2.84)

0.778

1.73 (0.66–4.94)

0.264

Etiology (viral/non-viral)

1.01 (0.79–1.27)

0.959

2.17 (0.61–8.28)

0.227

Child-Pugh class (A/B)

0.87 (0.74–0.96)

0.003

0.85 (0.69–0.98)

0.022

AFP (≤400/>400) ng/ml

0.83 (0.76–0.93)

<0.001

0.81 (0.74–0.93)

0.011

Albumin (>3.6/≤3.6) g/dL

0.88 (0.71–0.91)

0.049

1.26 (0.52–6.41)

0.231

Hemoglobin (>11/≤11) g/dL

0.72 (0.64–0.88)

0.044

1.41 (0.59–6.86)

0.213

PVTT (no/yes)

2.36 (0.87–6.39)

0.091

1.66 (0.68–5.12)

0.121

BED (>65.5/≤65.5) Gy10

0.78 (0.69–0.92)

0.023

0.81 (0.71–0.93)

0.032

RT duration (≤37/>37) days

1.07 (0.92–6.34)

0.029

1.52 (0.41–5.24)

0.512

  1. PVTT portal vein tumor thrombus, HCC hepatocellular carcinoma, ECOG Eastern Cooperative Oncology Group, BED biologically effective dose, RT radiation therapy, AFP Alpha-fetoprotein