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Table 3 Predictive factors for local control

From: Feasibility and efficacy of helical tomotherapy in cirrhotic patients with unresectable hepatocellular carcinoma

  Univariate analysis   Multivariate analysis  
Parameters Hazard ratio (95 % CI) P value Hazard ratio (95 % CI) P value
Age (≤67/>67) years 1.13 (0.49–2.78) 0.772 1.01 (0.97–1.07) 0.762
Gender (male/female) 0.75 (0.31–1.76) 0.519 1.33 (0.46–3.95) 0.585
ECOG score (0–1/2) 1.13 (0.48–2.84) 0.778 1.73 (0.66–4.94) 0.264
Etiology (viral/non-viral) 1.01 (0.79–1.27) 0.959 2.17 (0.61–8.28) 0.227
Child-Pugh class (A/B) 0.87 (0.74–0.96) 0.003 0.85 (0.69–0.98) 0.022
AFP (≤400/>400) ng/ml 0.83 (0.76–0.93) <0.001 0.81 (0.74–0.93) 0.011
Albumin (>3.6/≤3.6) g/dL 0.88 (0.71–0.91) 0.049 1.26 (0.52–6.41) 0.231
Hemoglobin (>11/≤11) g/dL 0.72 (0.64–0.88) 0.044 1.41 (0.59–6.86) 0.213
PVTT (no/yes) 2.36 (0.87–6.39) 0.091 1.66 (0.68–5.12) 0.121
BED (>65.5/≤65.5) Gy10 0.78 (0.69–0.92) 0.023 0.81 (0.71–0.93) 0.032
RT duration (≤37/>37) days 1.07 (0.92–6.34) 0.029 1.52 (0.41–5.24) 0.512
  1. PVTT portal vein tumor thrombus, HCC hepatocellular carcinoma, ECOG Eastern Cooperative Oncology Group, BED biologically effective dose, RT radiation therapy, AFP Alpha-fetoprotein