Table 1 Clinicopathological features of colorectal cancer with PTEN alteration
IHC | Methylation | DNA copy number | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Loss | Intact | p | Hyper | Normal | p | Decrease | Normal | p | ||
Case no.(%) | 68(34.3) | 130(65.7) | 54(27.3) | 144(72.7) | 36(18.2) | 162(81.8) | ||||
Gender | ||||||||||
Male | 127(64.1) | 43(33.9) | 84(66.1) | 0.877 | 36(28.3) | 91(71.7) | 0.740 | 15(11.8) | 112(88.2) | 0.002 |
Female | 71(35.9) | 25(35.2) | 46(64.8) | 18(25.4) | 53(74.6) | 21(29.6) | 50(70.4) | |||
Location | ||||||||||
Rectum | 61(30.8) | 17(27.9) | 44(72.1) | 0.200 | 13(21.3) | 48(78.7) | 0.209 | 11(18.0) | 50(82.0) | 0.971 |
Colon | 137(69.2) | 51(37.2) | 86(62.8) | 41(29.9) | 96(70.1) | 25(18.2) | 112(81.8) | |||
TNM Stage | ||||||||||
I | 50(25.3) | 10(20.0) | 40(80.0) | 0.001 | 18(36.0) | 32(64.0) | 0.354 | 11(22.0) | 39(78.0) | 0.446 |
II | 48(24.2) | 13(27.1) | 35(72.9) | 11(22.9) | 37(77.1) | 5(10.4) | 43(89.6) | |||
III | 49(24.7) | 16(32.7) | 33(67.3) | 14(28.6) | 35(71.4) | 10(20.4) | 39(79.6) | |||
IV | 51(25.8) | 29(56.9) | 22(43.1) | 11(21.6) | 40(78.4) | 10(19.6) | 41(80.4) | |||
CEA level | ||||||||||
High | 68(34.3) | 31(45.6) | 37(54.4) | 0.019 | 19(27.9) | 49(72.1) | 0.879 | 14(20.6) | 54(79.4) | 0.525 |
Normal | 130(65.7) | 37(28.5) | 93(71.5) | 35(26.9) | 95(73.1) | 22(16.9) | 108(83.1) | |||
Differentiation | ||||||||||
Poor | 14(7.1) | 2(14.3) | 14(85.7) | 0.145 | 5(35.7) | 9(64.3) | 0.535 | 3(21.4) | 11(78.6) | 0.722 |
Mod/well | 184(92.9) | 66(35.9) | 118(64.1) | 9(26.2) | 135(73.4) | 33(17.9) | 151(82.1) | |||
LVI | ||||||||||
Present | 49(24.7) | 21(42.9) | 28(57.1) | 0.148 | 14(28.6) | 35(71.4) | 0.814 | 11(22.4) | 38(77.6) | 0.372 |
Absent | 149(75.3) | 47(31.5) | 102(68.5) | 40(26.8) | 109(73.2) | 25(16.8) | 124(83.2) | |||
Mucinous histology | ||||||||||
Present | 20(10.1) | 8(40.0) | 12(60.0) | 0.574 | 4(20.0) | 16(80.0) | 0.441 | 4(20.0) | 16(80.0) | 0.824 |
Absent | 178(89.9) | 60(33.7) | 118(66.3) | 50(28.1) | 128(71.9) | 32(18.0) | 146(82.0) | |||