Table 1 Clinical data of patients with solitary lung metastasis of prostatic cancer
Author | Year | Age (years) | Initial characteristic | Initial treatment | Adjuvant/salvage treatment | Lung meta. characteristics | Solitary lung meta. treatment | Pathology | Outcome |
|---|---|---|---|---|---|---|---|---|---|
Present case |  | 50 | PSA 61.7, cT4, GS4 + 5 | Neoadjuvant endocrine therapy radiation therapy | None | Left S5, 3 cm | Lobectomy and mediastinal LND | PSAP (+), chromogranin (+), synaptophysin (+), CD56/CD57 (+), surfactant apoprotein (−), CK20/CK7 (−), mediastinal LN meta | Died 2.5 years after metastases detected |
Pepe et al. [6] | 2012 | 75 | PSA 8.3, pT3a, GS4 + 3, mixed acinar and ductal prostate ca | Radical prostatectomy | None | Left S6, 2 cm | Metastatectomy | PSAP (+), TTF-1 (−) | Undetectable |
Sakai et al. [7] | 2010 | 74 | Unknown | Neoadjuvant endocrine therapy radiation therapy | Neoadjuvant endocrine therapy | Left S8, 2.2 cm | Wedge resection | PSAP (+), P504 (+), pleural dissemination | Undetectable |
Goto et al. [9] | 2010 | 73 | PSA 14.37, GS4 + 5, pT4, P/D adenoca with sarcomatoid carcinoma component | Nneoadjuvant endocrine therapy. pelvic evisceration | None | Left S3, 2 cm | Wedge resection | PSAP (−), cytokeratin A/E1/3 (+), cytokeratin7 (−), cytokeratin20 (−), vimentin (−), undifferentiated carcinoma | Undetectable |
Boyer et al. [13] | 2009 | 65 | PSA 3, GS3 + 3, pT2 | Radical prostatectomy | None | Left upper lobe, 2.8 cm | Surgical resection | Unknown | Undetectable |
Khandani et al. [12] | 2009 | 78 | Prostate cancer only | Radiation therapy | None | Left S10, 5 cm | Lobectomy and mediastinal LND | PSAP (−) | Undetectable |
Pruthi et al. [10] | 2007 | 72 | PSA 4.1, GS3 + 3, pT2b | radical prostatectomy | salvage radiation therapy | left S8, 2 cm | endocrine therapy and surgical resection | PSAP (+), GS 8, subcarinal LN meta | 3-year disease free follow up |
Chao et al. [4] | 2004 | 68 | PSA 6.7, GS4 + 5, pT2a | Radical prostatectomy | None | Left lower lobe, 1.2 cm | Wedge resection | PSAP (+), W-M/D adenoca | 12-year disease free follow up |
Hofland et al. [8] | 2000 | 49 | GS 4 + 5, pT3c, P/D adenoca | Radical prostatectomy | Salvage radiation therapy, endocrine therapy and orchiectomy | Left lower lobe only | Lobectomy | PSAP (+), P/D adenoca | Metastases, undetectable |
Smith et al. [5] | 1999 | 70 | GS4 + 5, pT2 | Radical prostatectomy | None | Right S7, 2 cm | Surgical resection | PSAP (+), P/D adenoca | Undetectable |
Rockey et al. [14] | 1990 | 83 | Low grade prostate cancer only | Radiation therapy | None | Left lower lobe only | Orchiectomy | PSAP (+), meta. Only | Undetectable |
Fabozzi et al. [3] | 1995 | 11 cases: details unknown | |||||||
Varkarakis et al. [11] | 1974 | One case, details unknown | |||||||