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Table 1 Characteristics of spinal cases of TIO

From: En bloc resection for treatment of tumor-induced osteomalacia: a case presentation and a systematic review

Number

Authors, year

c

Age, sex

Period (years)

symptoms

Preoperative lab

Treatment

Histological diagnosis

Outcomes

1

Boriani et al, 1978 [8]

S1-3

18, M

DNMI

Bone pain, weakness

Hypophosphatemia, elevated ALP

Complete resection, radiotherapy

Osteosarcoma

NOLF

2

Stone et al, 1992 [9]

T3-4

33, F

DNMI

Bone pain, weakness, fractures

Hypophosphatemia

Complete resection, supplementation of vitamin D, phosphate, and calcium

Neuroendocrine tumor

NOLF

3

Yu et al, 1995 [10]

C2

58, F

DNMI

Musculoskeletal pain, weakness

Hypophosphatemia, elevated ALP and PTH

Partial resection, supplementation of vitamin D and phosphate

PMT

PSA

4

Terek et al, 2001 [11]

S1-2

14, M

1+

Bone pain, skeletal abnormalities

Hypophosphatemia, hypocalcemia, low level of vitamin D3, elevated ALP

Partial resection, chemotherapy (doxorubicin)

Osteosarcoma

PSA, ALL

5

Dissanayake et al, 2003 [37]

L2

58, M

3+

Musculoskeletal pains, fractures

Hypophosphatemia, low level of vit D3, elevated ALP

Complete resection

Haemangiopericytoma

NOLF

6

Folpe et al, 2004 [5]

C1

32, F

4

DNMI

DNMI

Partial resection, radiotherapy

Malignant PMTMCT

PSA recurrence

7

Chua et al, 2008 [12]

T3

34, F

1

Musculoskeletal pain, fatigue

Hypophosphatemia, hypocalcemia, elevated ALP and PTH

Partial resection, supplementation of phosphate and calcitriol

Plasmacytoma

DNMI

8

Sciubba et al, 2009 [13]

T8

56, F

5

Bone pain, weakness, fractures

Hypophosphatemia, low level of vitamin D3, elevated ALP and PTH

Complete resection

PMT

NOLF

9

Pirola et al, 2009 [14]

T4

57, M

DNMI

Fractures, paresthesias

Hypophosphatemia, low level of vitamin D3, elevated ALP and PTH

Complete resection, supplementation of vitamin D and phosphate

PMT

NOLF

10

Mavrogenis et al, 2010 [15]

S1

42, F

2

Bone pain, paresthesias

Normal

Complete resection

PMTMCT

NOLF

11

Marshall et al, 2010 [16]

T12

55, F

6+

Bone pain; fractures

Hypophosphatemia

Complete resection

PMTMCT

DNMI

12

Akhter et al, 2011 [17]

C5

52, M

1

Fracture

Hypophosphatemia

Complete resection, supplementation of vitamin D, and phosphate

PMTMCT

NOLF

13

Gandhi et al, 2012 [18]

L4

66, F

2,

Bone pain, weakness

Hypophosphatemia, hypocalcemia, low level of vit D3, elevated ALP and PTH

Complete resection

PMTMCT

NOLF

14

Nakamura et al, 2014 [19]

C5

72, M

2.5

Weakness

Hypophosphatemia, elevated ALP and PTH

Complete resection, supplementation of phosphate and calcitriol.

PMTMCT

NOLF

15

Puthenveetil et al [38]

T12

61, F

7

Musculoskeletal pain, weakness, fractures

Hypophosphatemia, increased ALP

Complete resection, supplementation of calcium and phosphate

PMTMCT

NOLF

16

Present case

T1

60, M

6

Bone pain, weakness, paresthesia

Hypophosphatemia, hypocalcemia, elevated PTH

Complete resection, supplementation of calcitriol

PMT

NOLF

  1. PMTMCT: phosphaturic mesenchymal tumor mixed connective tissue type; PMT: phosphaturic mesenchymal tumor; DNMI: Did not mention it; PSA: persistent serum abnormalities; ALP: alkaline phosphatase; NOLF: normalization of lab findings; ALL: acute lymphocytic leukemia.