Table 1 Characteristics of 16 studies of HCV infection and the risk of cholangiocarcinoma
Study | Country | CCA type | Demographics | Case (n) | Control (n) | Sources | OR (95% CI) | Adjustments | |
|---|---|---|---|---|---|---|---|---|---|
Age (Y) | Sex (% M) | ||||||||
Liu (2011) [7] | China | ICC | ≧50 | 39 | 87 | 228 | Hospital-based | 0.87 (0.09 to 18.50) | NR |
Shin (1996) [9] | Korea | ICC | 59 | 73.2 | 41 | 406 | Hospital-based | 6.80 (2.30 to 20.30) | age, sex |
Donato (20011) [10] | Italy | ICC | 65 | 80.8 | 26 | 824 | Hospital-based | 9.70 (1.60 to 58.90) | sex, age, residence |
Zhou (2008) [15] | China | ICC | 53.2 | 66 | 312 | 438 | Hospital-based | 0.93 (0.28 to 3.10) | age, sex |
Shaib (2005) [12] | United States | ICC | 78.7 | 51.7 | 625 | 90,834 | Population-based | 6.10 (4.30 to 8.60) | age, sex, race, geographic location, |
Shaib (2007) [13] | United States | ICC | 59.8 | 55.4 | 83 | 236 | Hospital-based | 7.90 (1.30 to 84.50) | age, ethnicity, anti-HCV, HbsAg anti-HBc, alcohol consumption |
ECC | 61.1 | 67.6 | 163 | 2.80 (0.30 to 35.10) | |||||
Yamamoto (2004) [11] | Japan | ICC | 64.6 | 58 | 50 | 205 | Hospital-based | 6.02 (1.51 to 24.1) | aspartate aminotransferase, blood transfusion, diabetes mellitus |
Welzel (2007) [14] | United States | ICC | 79 | 48 | 535 | 102,782 | Population-based | 4.40 (1.40 to 140) | age, race, geographic region |
ECC | 78.7 | 51 | 549 | 1.50 (0.20 to 11.00) | |||||
Lee (2008) [17] | South Korea | ICC | 60.7 | 69.1 | 622 | 2,488 | Hospital-based | 1.00 (0.50 to 1.90) | age, sex |
Hsing (2008) [18] | China | ECC | 67 | 58.2 | 134 | 762 | Population-based | 0.80 (0.20 to 3.40) | education, smoking, BMI, diabetes, gallstones |
Tao (2009) [20] | China | ICC | ≧50 | 60.7 | 61 | 380 | Hospital-based | 6.30 (0.40 to 102.30) | NR |
Lee (2009) [19] | Taiwan, Republic of China | ICC | 61.5 | 63.1 | 160 | 160 | Hospital-based | 2.71 (1.16 to 6.32) | NR |
Srivatanakul (2010) [21] | Thailand | CCA | NR | NR | 103 | 103 | Hospital-based | 7/0 (1.44 to infinity) | anti-OV Ab |
Welzel (2011) [23] | United States | ICC | 76.4 | 47.5 | 743 | 195,953 | Population-based | 8.05 (5.08 to 12.75) | age, sex, race, geographic location |
Cai (2011) [22] | China | ICC | 56.6 | 62.0 | 313 | 608 | Hospital-based | NR | NR |
Qu (2012) [24] | China | ECC | 63 | 63.9 | 305 | 480 | Hospital-based | NR | NR |