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Table 7 Features of sarcomatoid adrenal cortical carcinomas reported to date

From: Diagnostic and prognostic features in adrenocortical carcinoma: a single institution case series and review of the literature

Reference Age Sex Clinical presentation Laterality Size Treatment Time to recurrence Time to death
Okazumi et al. [74] 46 M Abdominal distention + back pain Right 14 cm Right adrenalectomy and nephrectomy followed by removal of the tumor thrombus 5 months 206 days
Collina et al. [75] 68 F Abdominal discomfort Right 11 cm Surgical resection followed by radiotherapy after tumor recurrence 2 months 6 months
Decorato et al. [76] 42 F Abdominal pain Left 19 cm Surgical resection 3 months 7 months
Fischler et al. [77] 29 F Virilization Left 12.5 cm Nephroadrenalectomy and splenectomy followed by systemic chemotherapy (cisplatin and etoposide) after recurrence 4 months 8 months
Barksdale et al. [78] 79 F Severe hypertension Right 9 cm Right adrenalectomy and cavotomy 4 months Not reported
Lee et al. [79] 61 M Flank pain + hypertension Right 12 cm Radical nephrectomy and right hepatic lobectomy No recurrence noted 2 days
Sturm et al. [7] 31 M Abdominal pain Left 12 cm Adrenalectomy followed by systemic chemotherapy (VP16-cisplatinum) after recurrence 2 months 3 months
Coli et al. (2009) [80] 75 F Abdominal pain Left 15 cm Adrenalectomy and splenectomy 3 months 12 months
Feng et al. [81] 72 M Left lumbar pain Left 7.1 cm on CT scan Surgical resection Not reported Not reported
Sasaki et al. [82] 45 M Abdominal pain, fever, nausea, vomiting, anorexia, hypertension Left 17 cm Radical nephrectomy, splenectomy, distal pancreatectomy, left partial colectomy, and wedge biopsy of one hepatic lesion Hepatic metastasis at presentation. Locoregional recurrence at 3 months 3 months
Bertolini et al. [83] 23 F Incidentally during work-up of metastatic rectal mass Left 14 cm Left adrenalectomy with systemic chemotherapy for metastatic rectal cancer Not reported, however patient had metastatic lesions on presentation which were presumed to be rectal cancer based on the co-existence of a metastatic rectal cancer lesion in the adrenal gland 14 months
Thway et al. [84] 45 M Abdominal bloating + back pain Left 24 cm Left radical nephrectomy and splenectomy followed by palliative chemotherapy (vincristine, ifosfamide, carboplatin, doxorubicin, and etoposide) Metastatic at presentation 11 months
Yan et al. [85] 72 M Flank pain Right 13 cm Adrenalectomy 2 years 2.5 years
Kao et al. [86] 48 F Abdominal pain + hypokalemia + weight loss Right 15 cm Adrenalectomy, partial nephrectomy, and partial hepatectomy followed by systemic chemotherapy (cisplatin and ifosfamide) after distant metastasis 2 months Alive with disease at 7 month follow-up
Mark et al. [87] 58 M Flank pain Right 12 cm Radial nephrectomy followed by eternal beam radiotherapy to the tumor site Not reported after 16 month follow-up Not reported after 16 month follow-up
Shaikh et al. [88] 62 F Abdominal pain Right 6.5 cm Adrenalectomy 3 months 4 months
  1. CT, computed tomography; F, female; M, male.