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Table 6 van Slooten criteria

From: Diagnostic and prognostic features in adrenocortical carcinoma: a single institution case series and review of the literature

Criteria

Numeric value

Regressive changes such as necrosis, hemorrhage, fibrosis, or calcification

5.7

Loss of normal structure

1.6

Nuclear atypia

2.1

Nuclear hyperchromasia

2.6

Abnormal nucleoli structure

4.1

Mitotic activity >2/10 HPFs

9.0

Capsular or vascular invasion

3.3

  1. HPFs, high-powered fields.