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Table 6 van Slooten criteria

From: Diagnostic and prognostic features in adrenocortical carcinoma: a single institution case series and review of the literature

Criteria Numeric value
Regressive changes such as necrosis, hemorrhage, fibrosis, or calcification 5.7
Loss of normal structure 1.6
Nuclear atypia 2.1
Nuclear hyperchromasia 2.6
Abnormal nucleoli structure 4.1
Mitotic activity >2/10 HPFs 9.0
Capsular or vascular invasion 3.3
  1. HPFs, high-powered fields.