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Table 4 Largest ACC case series published to date ( n> 300)

From: Diagnostic and prognostic features in adrenocortical carcinoma: a single institution case series and review of the literature

Reference Published year Country Database Number of patients Average Age (years) Male-to-female ratio Median tumor size (cm) Proportion of tumors with distant metastasis at presentation (%)
Kutikov et al. [4] 2011 United States National Cancer Database 4,275 54.5 41.9% to 58.1% 11.5 34.4
Kebebew et al. [3] 2006 United States Surveillance, Epidemiology, and End Results (SEER) Database 725 51.2 45.9% to 54.1% 12 34.8
Fassnacht et al. [8] 2009 Germany The German ACC Registry 416 46.7 37.3% to 62.7% 11.3 29.3
Else et al. [9] 2014 United States Michigan Endocrine Oncology Repository 391 47.4 40% to 60% 11.8 29
Kerkhofs et al. [2] 2013 Netherlands Netherlands Cancer Registry 359 56 45% to 55% Not available 35
Ayala-Ramirez et al. [10] 2013 United States Tumor Registry Database at the University of Texas MD Anderson Cancer Center 330 48.5 35.8% to 64.2% 11 cm 25.8