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Table 4 Largest ACC case series published to date ( n> 300)

From: Diagnostic and prognostic features in adrenocortical carcinoma: a single institution case series and review of the literature

Reference

Published year

Country

Database

Number of patients

Average Age (years)

Male-to-female ratio

Median tumor size (cm)

Proportion of tumors with distant metastasis at presentation (%)

Kutikov et al. [4]

2011

United States

National Cancer Database

4,275

54.5

41.9% to 58.1%

11.5

34.4

Kebebew et al. [3]

2006

United States

Surveillance, Epidemiology, and End Results (SEER) Database

725

51.2

45.9% to 54.1%

12

34.8

Fassnacht et al. [8]

2009

Germany

The German ACC Registry

416

46.7

37.3% to 62.7%

11.3

29.3

Else et al. [9]

2014

United States

Michigan Endocrine Oncology Repository

391

47.4

40% to 60%

11.8

29

Kerkhofs et al. [2]

2013

Netherlands

Netherlands Cancer Registry

359

56

45% to 55%

Not available

35

Ayala-Ramirez et al. [10]

2013

United States

Tumor Registry Database at the University of Texas MD Anderson Cancer Center

330

48.5

35.8% to 64.2%

11 cm

25.8