Diagnostic and prognostic features in adrenocortical carcinoma: a single institution case series and review of the literature

Table 4 Largest ACC case series published to date ( n > 300)

Reference	Published year	Country	Database	Number of patients	Average Age (years)	Male-to-female ratio	Median tumor size (cm)	Proportion of tumors with distant metastasis at presentation (%)
Kutikov et al. [4]	2011	United States	National Cancer Database	4,275	54.5	41.9% to 58.1%	11.5	34.4
Kebebew et al. [3]	2006	United States	Surveillance, Epidemiology, and End Results (SEER) Database	725	51.2	45.9% to 54.1%	12	34.8
Fassnacht et al. [8]	2009	Germany	The German ACC Registry	416	46.7	37.3% to 62.7%	11.3	29.3
Else et al. [9]	2014	United States	Michigan Endocrine Oncology Repository	391	47.4	40% to 60%	11.8	29
Kerkhofs et al. [2]	2013	Netherlands	Netherlands Cancer Registry	359	56	45% to 55%	Not available	35
Ayala-Ramirez et al. [10]	2013	United States	Tumor Registry Database at the University of Texas MD Anderson Cancer Center	330	48.5	35.8% to 64.2%	11 cm	25.8

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