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Table 3 Clinicopathologic characteristics of familial and sporadic PTC patients

From: Single-center study of familial papillary thyroid cancer in China: surgical considerations

Characteristics Familial ( n= 22) Sporadic ( n= 226) P value
Gender    0.0514
   Male 2(9.10%) 64(28.3%)  
   Female 20(91.0%) 162(71.7%)  
Age (years, mean ± SD) 36.64 ± 13.95 40.77 ± 13.30 0.168
Tumor size    0.0024
   >4 cm 8(36.4%) 28(12.4%)  
   ≤4 cm 14(63.6%) 198(87.6%)  
Tumor aggressiveness: n(%)    
   Multifocality 12(54.50%) 60(26.50%) 0.006
   Rapid proliferation 4(18.2%) 32(14.0%) 0.597
   Local invasiona 18(81.8%) 54(23.9%) <0.001
   Malignant lymph nodes 14(63.6%) 76(33.6%) 0.005
Number of tLNs: median (range) 7(0 to 37) 9(0 to 119) 0.660
Number of mLNs: median (range) 1(0 to 19) 0(0 to 33) 0.125
Combined with benign thyroid diseases 14(63.6%) 136(60.2%) 0.751
AJCC stage    
   Age <45    1.00
   I 12(54.5%) 134(59.3%)  
   II 0 8(3.54%)  
   Age ≥45    0.306
   I + II 6(27.3%) 32(14.2%)  
   III + IV 4(18.2%) 52(23.0%)  
Relapse 3(13.6%) 14(6.2%) 0.182
  1. SD: standard deviation, tLN: total resected lymph nodes, mLN: metastatic lymph nodes, AJCC: American Joint Committee on Cancer. aLocal invasion including minimal extrathyroidal extension and invasion to esophagus, larynx, recurrent laryngeal nerve, and subcutaneous soft tissues.