Table 3 Clinicopathologic characteristics of familial and sporadic PTC patients
From: Single-center study of familial papillary thyroid cancer in China: surgical considerations
Characteristics | Familial ( n = 22) | Sporadic ( n = 226) | P value |
|---|---|---|---|
Gender | 0.0514 | ||
Male | 2(9.10%) | 64(28.3%) | |
Female | 20(91.0%) | 162(71.7%) | |
Age (years, mean ± SD) | 36.64 ± 13.95 | 40.77 ± 13.30 | 0.168 |
Tumor size | 0.0024 | ||
>4 cm | 8(36.4%) | 28(12.4%) | |
≤4 cm | 14(63.6%) | 198(87.6%) | |
Tumor aggressiveness: n(%) | |||
Multifocality | 12(54.50%) | 60(26.50%) | 0.006 |
Rapid proliferation | 4(18.2%) | 32(14.0%) | 0.597 |
Local invasiona | 18(81.8%) | 54(23.9%) | <0.001 |
Malignant lymph nodes | 14(63.6%) | 76(33.6%) | 0.005 |
Number of tLNs: median (range) | 7(0 to 37) | 9(0 to 119) | 0.660 |
Number of mLNs: median (range) | 1(0 to 19) | 0(0 to 33) | 0.125 |
Combined with benign thyroid diseases | 14(63.6%) | 136(60.2%) | 0.751 |
AJCC stage | |||
Age <45 | 1.00 | ||
I | 12(54.5%) | 134(59.3%) | |
II | 0 | 8(3.54%) | |
Age ≥45 | 0.306 | ||
I + II | 6(27.3%) | 32(14.2%) | |
III + IV | 4(18.2%) | 52(23.0%) | |
Relapse | 3(13.6%) | 14(6.2%) | 0.182 |