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Table 1 Study and patient characteristics of each randomized controlled trial

From: Radiofrequency ablation versus percutaneous ethanol injection for hepatocellular carcinoma: a meta-analysis of randomized controlled trials

First author, year Duration Region Randomization Tx ( n ) Age, years Sex, n (M/F) Child-Pugh, n (A/B) Infection, n (HBV/HCV/others) Tumors, n (1/>2) Ratio of tumor, n (≤3/> 3 cm) Tumor size, cm Albumin, g/dL Volume per session, mL Number of sessions Follow-up, months Jadad score
Lencioni, 2003 April 2000 to April 2002 Italy Computer RFA (52) 6 ± 6.0 36/16 45/7 6/22/24 40/12 46/6 2.8 ± 0.6 4.1 ± 0.7 NA 1.1 ± 0.5 22.9 ± 9.4 4
     PEI (50) 6 ± 7.4 30/20 35/15 9/20/21 31/19 42/8 2.8 ± 0.8 3.7 ± 0.6 NA 5.4 ± 1.6 22.4 ± 8.6  
Lin, 2004 April 2000 to April 2002 Taiwan Computer RFA (52) 62 ± 11 35/17 41/11 35/16/1 38/14 37/15 2.9 ± 0.8 3.7 ± 0.8 NA 1.6 ± 0.4 24.5 ± 11.3 4
     PEI (52) 59 ± 10 34/18 39/12 37/14/1 40/12 38/14 2.8 ± 0.8 3.8 ± 1.0 4.5 (2.0–10.0) 6.5 ± 1.6 23.8 ± 10.4  
Lin, 2005 April 2000 to April 2003 Taiwan Computer RFA (62) 61 ± 10 40/22 46/16 41/20/1 49/13 62/0 2.5 ± 1.0 4.0 ± 0.6   1.3 ± 0.3 28 ± 12 4
     PEI (62) 60 ± 8 39/23 47/15 42/19/1 49/13 62/0 2.3 ± 0.8 3.9 ± 0.4 4.8 (2.0–10.4) 4.9 ± 1.3 26 ± 13  
Shiina, 2005 April 1999 to January 2001 Japan Computer RFA (118) 44/71 (≤65/> 65) 79/39 85/33 18/90/10 72/46 118/0 NA 60/58 (≤3.5/> 3.5) 2–8 2.1 ± 1.3 37 4
     PEI (114) 41/73 (≥65/> 65) 87/27 85/29 11/98/5 60/54 114/0 NA 49/65 (≤3.5/> 3.5) NA 6.4 ± 2.6 35  
Brunello, 2008 January 2001 to September 2004 Italy Computer RFA (70) 69.0 ± 7.7 43/27 39/31 6/44/20 54/16 70/0 2.42 ± 0.49 3.45 ± 0.69 2–20 NA 26.1 4
     PEI (69) 70.3 ± 8.1 49/20 39/30 0/47/22 54/15 69/0 2.25 ± 0.54 3.42 ± 0.55 NA NA 25.3  
Giorgio, 2011 January 2005 to January 2010 Italy RNG RFA (128) 70 ± 2 105/37 70/72 61/81/0 128 128/0 2.34 ± 0.45 3.37 ± 0.87 8.7 (4.0–20.0) 5 22 4
     PEI (143) 72 ± 6 102/41 75/68 56/87/0 143 143/0 2.27 ± 0.48 3.41 ± 0.92 NA 8 22  
Wang, 2011 January 2001 to March 2009 China NA RFA (49) 43 35/14 NA NA NA NA 2.4 ± 1.2 NA NA NA 11.2 ± 1.3 2
     PEI (49) 45 36/13 NA NA NA NA 2.3 ± 1.4 NA   NA 11.2 ± 1.3  
Azab, 2011 2005 to 2008 Egypt NA RFA (30) NA NA NA NA NA 16/17 NA NA 3–14 1.45 NA 3
     PEI (30) NA NA NA NA NA 16/16 NA NA   7.68 NA  
  1. HBV, hepatitis B virus; HCV, hepatitis C virus; NA, not available; PEI, percutaneous ethanol injection; RFA, radiofrequency ablation; RNG, random number generator; Tx, treatment.
  2. Data are presented as mean ± standard deviation or mean (range).