Table 1 Study and patient characteristics of each randomized controlled trial
First author, year | Duration | Region | Randomization | Tx ( n ) | Age, years | Sex, n (M/F) | Child-Pugh, n (A/B) | Infection, n (HBV/HCV/others) | Tumors, n (1/>2) | Ratio of tumor, n (≤3/> 3 cm) | Tumor size, cm | Albumin, g/dL | Volume per session, mL | Number of sessions | Follow-up, months | Jadad score |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Lencioni, 2003 | April 2000 to April 2002 | Italy | Computer | RFA (52) | 6 ± 6.0 | 36/16 | 45/7 | 6/22/24 | 40/12 | 46/6 | 2.8 ± 0.6 | 4.1 ± 0.7 | NA | 1.1 ± 0.5 | 22.9 ± 9.4 | 4 |
|  |  |  |  | PEI (50) | 6 ± 7.4 | 30/20 | 35/15 | 9/20/21 | 31/19 | 42/8 | 2.8 ± 0.8 | 3.7 ± 0.6 | NA | 5.4 ± 1.6 | 22.4 ± 8.6 |  |
Lin, 2004 | April 2000 to April 2002 | Taiwan | Computer | RFA (52) | 62 ± 11 | 35/17 | 41/11 | 35/16/1 | 38/14 | 37/15 | 2.9 ± 0.8 | 3.7 ± 0.8 | NA | 1.6 ± 0.4 | 24.5 ± 11.3 | 4 |
|  |  |  |  | PEI (52) | 59 ± 10 | 34/18 | 39/12 | 37/14/1 | 40/12 | 38/14 | 2.8 ± 0.8 | 3.8 ± 1.0 | 4.5 (2.0–10.0) | 6.5 ± 1.6 | 23.8 ± 10.4 |  |
Lin, 2005 | April 2000 to April 2003 | Taiwan | Computer | RFA (62) | 61 ± 10 | 40/22 | 46/16 | 41/20/1 | 49/13 | 62/0 | 2.5 ± 1.0 | 4.0 ± 0.6 |  | 1.3 ± 0.3 | 28 ± 12 | 4 |
|  |  |  |  | PEI (62) | 60 ± 8 | 39/23 | 47/15 | 42/19/1 | 49/13 | 62/0 | 2.3 ± 0.8 | 3.9 ± 0.4 | 4.8 (2.0–10.4) | 4.9 ± 1.3 | 26 ± 13 |  |
Shiina, 2005 | April 1999 to January 2001 | Japan | Computer | RFA (118) | 44/71 (≤65/> 65) | 79/39 | 85/33 | 18/90/10 | 72/46 | 118/0 | NA | 60/58 (≤3.5/> 3.5) | 2–8 | 2.1 ± 1.3 | 37 | 4 |
|  |  |  |  | PEI (114) | 41/73 (≥65/> 65) | 87/27 | 85/29 | 11/98/5 | 60/54 | 114/0 | NA | 49/65 (≤3.5/> 3.5) | NA | 6.4 ± 2.6 | 35 |  |
Brunello, 2008 | January 2001 to September 2004 | Italy | Computer | RFA (70) | 69.0 ± 7.7 | 43/27 | 39/31 | 6/44/20 | 54/16 | 70/0 | 2.42 ± 0.49 | 3.45 ± 0.69 | 2–20 | NA | 26.1 | 4 |
|  |  |  |  | PEI (69) | 70.3 ± 8.1 | 49/20 | 39/30 | 0/47/22 | 54/15 | 69/0 | 2.25 ± 0.54 | 3.42 ± 0.55 | NA | NA | 25.3 |  |
Giorgio, 2011 | January 2005 to January 2010 | Italy | RNG | RFA (128) | 70 ± 2 | 105/37 | 70/72 | 61/81/0 | 128 | 128/0 | 2.34 ± 0.45 | 3.37 ± 0.87 | 8.7 (4.0–20.0) | 5 | 22 | 4 |
|  |  |  |  | PEI (143) | 72 ± 6 | 102/41 | 75/68 | 56/87/0 | 143 | 143/0 | 2.27 ± 0.48 | 3.41 ± 0.92 | NA | 8 | 22 |  |
Wang, 2011 | January 2001 to March 2009 | China | NA | RFA (49) | 43 | 35/14 | NA | NA | NA | NA | 2.4 ± 1.2 | NA | NA | NA | 11.2 ± 1.3 | 2 |
|  |  |  |  | PEI (49) | 45 | 36/13 | NA | NA | NA | NA | 2.3 ± 1.4 | NA |  | NA | 11.2 ± 1.3 |  |
Azab, 2011 | 2005 to 2008 | Egypt | NA | RFA (30) | NA | NA | NA | NA | NA | 16/17 | NA | NA | 3–14 | 1.45 | NA | 3 |
| Â | Â | Â | Â | PEI (30) | NA | NA | NA | NA | NA | 16/16 | NA | NA | Â | 7.68 | NA | Â |