Table 3 Multivariate analysis of prognostic factors for overall survival ( n = 120)

Tumor size

1.423

0.990 to 2.044

0.056

Status of lymph nodes metastasis

2.222

1.172 to 4.210

0.014

Pathological stage

1.075

0.706 to 1.636

0.735

Positive P53 ^Mut labeling

1.320

0.834 to 2.091

0.236

Negative P16 labeling

0.360

0.226 to 0.572

<0.001

Negative Smad4 labeling

0.269

0.165 to 0.441

<0.001