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Table 2 Clinicopathological parameters and overall survival in 120 patients

From: Clinical outcome and expression of mutant P53, P16, and Smad4 in lung adenocarcinoma: a prospective study

   Mean (month) Median (month)  
  N Estimate 95% CI Estimate 95% CI P
Age (year)       
 ≤60 73 41.520 35.148 to 47.892 37.000 24.907 to 49.093 0.883
 >60 47 40.396 32.890 to 47.902 30.000 17.931 to 42.069  
Sex       
 M 58 41.563 34.672 to 48.454 36.000 18.585 to 53.415 0.917
 F 62 40.535 33.685 to 47.385 30.000 17.461 to 42.539  
Tumor size (cm)       
 T1 (≤3) 24 49.125 40.950 to 57.300 45.000 31.797 to 58.203 0.031
 T2 (3 to 7) 73 41.959 35.673 to 48.245 35.000 17.325 to 52.675  
 T3/4 (>7) 23 28.587 17.986 to 39.188 15.000 10.340 to 19.660  
Lymph nodes       
 Negative 71 50.437 44.488 to 56.387 49.000 39.870 to 58.130 <0.001
 Positive 49 27.497 20.990 to 34.003 17.000 13.571 to 20.429  
Differentiation       
 Well 32 48.869 40.548 to 57.190 49.000 33.785 to 64.215 0.067
 Moderate 41 43.975 35.538 to 52.412 35.000 16.180 to 53.820  
 Poor 47 33.009 25.461 to 40.556 21.000 14.283 to 27.717  
Pleural invasion       
 Negative 107 42.446 37.213 to 47.680 37.000 25.020 to 48.980 0.091
 Positive 13 31.385 18.335 to 44.434 23.000 15.954 to 30.046  
Stage       
 I 37 57.224 49.411 to 65.036 55.000 42.364 to 67.636 <0.001
 II 47 39.400 31.965 to 46.836 30.000 20.613 to 39.387  
 III 36 27.111 19.609 to 34.613 16.000 11.296 to 20.704  
Mutant P53       
 Negative 44 47.794 39.707 to 55.881 47.000 29.665 to 64.335 0.038
 Positive 76 37.172 31.317 to 43.027 30.000 20.511 to 39.487  
P16       
 Negative 54 28.352 22.689 to 34.014 20.000 14.399 to 25.601 <0.001
 Positive 66 51.359 44.929 to 57.788 56.000 40.849 to 71.151  
Smad4       
 Negative 75 30.185 25.074 to 35.297 21.000 15.346 to 26.654 <0.001
 Positive 45 59.678 52.491 to 66.866 66.000 50.912 to 81.088  
Gene expression combinations       <0.001
P53mut−/P16+/Smad4− 11 43.364 27.766 to 58.961 47.000 13.553 to 80.447  
P53mut−/P16+/Smad4+ 17 63.824 54.411 to 73.236 74.000 44.191 to 103.809  
P53mut−/P16−/Smad4+ 5 53.800 33.542 to 74.058 49.000 38.265 to 59.735  
P53mut−/P16−/Smad4− 11 22.000 14.791 to 29.209 21.000 14.746 to 27.254  
P53mut+/P16+/Smad4− 25 41.451 31.906 to 50.997 32.000 12.416 to 51.584  
P53mut+/P16+/Smad4+ 13 58.011 44.148 to 71.874 66.000 38.979 to 93.021  
P53mut+/P16−/Smad4+ 10 52.100 38.216 to 65.984 54.000 27.658 to 80.342  
P53mut+/P16−/Smad4− 28 18.185 14.057 to 22.313 15.000 12.976 to 17.024  
  1. The italicized values indicate P values less than 0.05.