Table 2 Clinicopathological parameters and overall survival in 120 patients
| Â | Â | Mean (month) | Median (month) | Â | ||
|---|---|---|---|---|---|---|
| Â | N | Estimate | 95% CI | Estimate | 95% CI | P |
Age (year) | Â | Â | Â | Â | Â | Â |
 ≤60 | 73 | 41.520 | 35.148 to 47.892 | 37.000 | 24.907 to 49.093 | 0.883 |
 >60 | 47 | 40.396 | 32.890 to 47.902 | 30.000 | 17.931 to 42.069 |  |
Sex | Â | Â | Â | Â | Â | Â |
 M | 58 | 41.563 | 34.672 to 48.454 | 36.000 | 18.585 to 53.415 | 0.917 |
 F | 62 | 40.535 | 33.685 to 47.385 | 30.000 | 17.461 to 42.539 |  |
Tumor size (cm) | Â | Â | Â | Â | Â | Â |
 T1 (≤3) | 24 | 49.125 | 40.950 to 57.300 | 45.000 | 31.797 to 58.203 | 0.031 |
 T2 (3 to 7) | 73 | 41.959 | 35.673 to 48.245 | 35.000 | 17.325 to 52.675 |  |
 T3/4 (>7) | 23 | 28.587 | 17.986 to 39.188 | 15.000 | 10.340 to 19.660 |  |
Lymph nodes | Â | Â | Â | Â | Â | Â |
 Negative | 71 | 50.437 | 44.488 to 56.387 | 49.000 | 39.870 to 58.130 | <0.001 |
 Positive | 49 | 27.497 | 20.990 to 34.003 | 17.000 | 13.571 to 20.429 |  |
Differentiation | Â | Â | Â | Â | Â | Â |
 Well | 32 | 48.869 | 40.548 to 57.190 | 49.000 | 33.785 to 64.215 | 0.067 |
 Moderate | 41 | 43.975 | 35.538 to 52.412 | 35.000 | 16.180 to 53.820 |  |
 Poor | 47 | 33.009 | 25.461 to 40.556 | 21.000 | 14.283 to 27.717 |  |
Pleural invasion | Â | Â | Â | Â | Â | Â |
 Negative | 107 | 42.446 | 37.213 to 47.680 | 37.000 | 25.020 to 48.980 | 0.091 |
 Positive | 13 | 31.385 | 18.335 to 44.434 | 23.000 | 15.954 to 30.046 |  |
Stage | Â | Â | Â | Â | Â | Â |
 I | 37 | 57.224 | 49.411 to 65.036 | 55.000 | 42.364 to 67.636 | <0.001 |
 II | 47 | 39.400 | 31.965 to 46.836 | 30.000 | 20.613 to 39.387 |  |
 III | 36 | 27.111 | 19.609 to 34.613 | 16.000 | 11.296 to 20.704 |  |
Mutant P53 | Â | Â | Â | Â | Â | Â |
 Negative | 44 | 47.794 | 39.707 to 55.881 | 47.000 | 29.665 to 64.335 | 0.038 |
 Positive | 76 | 37.172 | 31.317 to 43.027 | 30.000 | 20.511 to 39.487 |  |
P16 | Â | Â | Â | Â | Â | Â |
 Negative | 54 | 28.352 | 22.689 to 34.014 | 20.000 | 14.399 to 25.601 | <0.001 |
 Positive | 66 | 51.359 | 44.929 to 57.788 | 56.000 | 40.849 to 71.151 |  |
Smad4 | Â | Â | Â | Â | Â | Â |
 Negative | 75 | 30.185 | 25.074 to 35.297 | 21.000 | 15.346 to 26.654 | <0.001 |
 Positive | 45 | 59.678 | 52.491 to 66.866 | 66.000 | 50.912 to 81.088 |  |
Gene expression combinations | Â | Â | Â | Â | Â | <0.001 |
  P53mut−/P16+/Smad4− | 11 | 43.364 | 27.766 to 58.961 | 47.000 | 13.553 to 80.447 |  |
  P53mut−/P16+/Smad4+ | 17 | 63.824 | 54.411 to 73.236 | 74.000 | 44.191 to 103.809 |  |
  P53mut−/P16−/Smad4+ | 5 | 53.800 | 33.542 to 74.058 | 49.000 | 38.265 to 59.735 |  |
  P53mut−/P16−/Smad4− | 11 | 22.000 | 14.791 to 29.209 | 21.000 | 14.746 to 27.254 |  |
  P53mut+/P16+/Smad4− | 25 | 41.451 | 31.906 to 50.997 | 32.000 | 12.416 to 51.584 |  |
  P53mut+/P16+/Smad4+ | 13 | 58.011 | 44.148 to 71.874 | 66.000 | 38.979 to 93.021 |  |
  P53mut+/P16−/Smad4+ | 10 | 52.100 | 38.216 to 65.984 | 54.000 | 27.658 to 80.342 |  |
  P53mut+/P16−/Smad4− | 28 | 18.185 | 14.057 to 22.313 | 15.000 | 12.976 to 17.024 |  |