Figure 2

Clusterin silencing increased chemotherapeutic sensitivity and promoted apoptosis of DDP resistant A549 cells. (A) A549^DDP cells transfected with sCLU shRNA or scramble shRNA were injected subcutaneously into the right flank of nude mice. When tumors reached −100 mm³ in volume, the mice received daily 200 μl i.p. injections of DDP (4 mg/kg body/wt.,i.p). DDP was administered i.v. once every 3 days. The treatments lasted for 15 days during which the volume of tumors was recorded,*P < 0.05 (Student’s t test). (B) Tumor sections were stained with TUNEL agent to visualize apoptotic cells.^* P < 0.05 (Student’s t test).