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Table 4 Univariate analysis of prognostic factors on recurrence-free and overall survival

From: Clinical features and prognosis in hepatectomy for colorectal cancer with centrally located liver metastasis

 

Number of patient

5-year recurrence-free survival (%)

P values

5-year overall survival (%)

P values

Overall

159

20.8

 

34.6

 
    

39.6

(from diagnosis of primary CRC)

Gender

 Male

89

19.5

0.699

31.5

0.449

 Female

70

26.2

 

37.7

 

Location of the primary tumor(s)

 Transverse colon

18

6.1

0.020

16.7

0.014

 Other area (inclusive of synchronous)

141

24.4

 

36.4

 

Primary tumor staging

 T1, T2, or T3

71

29.0

0.057

42.9

0.017

 T4

88

17.3

 

27.3

 

Regional lymph node metastasis

 Negative

32

41.7

0.002

48.4

0.004

 Positive

127

17.7

 

30.7

 

Primary extrahepatic metastasis

 Negative

141

25.1

0.000

37.9

0.000

 Positive

18

0.0

 

5.6

 

Associated risky presentation(s)

 Negative

138

23.5

0.424

38.0

0.047

 Positive

21

15.1

 

9.5

 

Interval of liver metastasis

 Metachronous

55

38.9

0.001

48.1

0.001

 Synchronous

104

13.8

 

26.9

 

Involved hepatic segment(s)

 Single

59

27.7

0.054

40.7

0.040

 Multiple

100

19.3

 

30.3

 

Metastatic tumor distribution

 Unilobar

114

24.1

0.193

37.2

0.200

 Bilobar

45

18.2

 

26.7

 

Metastatic tumor location

 Peripherally located

135

25.0

0.017

38.8

0.002

 Centrally located

24

8.3

 

8.3

 

Maximal diameter of the largest metastasis

 <5 cm

129

24.5

0.122

38.8

0.008

 ≥5 cm

30

13.9

 

13.8

 

Number of liver metastasis

 Solitary

101

30.0

0.000

40.6

0.001

 Multiple

58

9.0

 

22.8

 

Differentiation of metastatic tumor

 Well differentiated

15

43.1

0.219 (well vs. moderately)

50.0

0.231 (well vs. moderately)

 Moderately differentiated

138

21.1

0.002 (moderately vs. poorly)

34.1

0.000 (moderately vs. poorly)

 Poorly differentiated

6

0.0

0.004 (well vs. poorly)

0.0

0.000 (well vs. poorly)

Mucinous adenocarcinoma

 Yes

13

23.1

0.813

38.5

0.922

 No

146

22.4

 

33.8

 

Neoadjuvant chemotherapy for liver metastasis

 Yes

15

20.0

0.677

35.7

0.477

 No

144

22.8

 

20.0

 

Anatomic resection for liver metastasis

 Yes

32

19.5

0.598

38.8

0.699

 No

127

23.2

 

33.1

 

Resection margin of metastatic tumor

 ≥10 mm

31

40.2

0.013

58.1

0.002

 <10 mm and involved

128

18.2

 

28.4

 

Recurrence after liver resection

 Early recurrence (<4 months)

33

  

0.0

0.000

 Late recurrence (≥4 months)

89

  

24.7

 

 Involved organ(s) while recurrent

 Confined in liver, lung or both

38

0.0

0.605

26.3

0.027

 Other distant organ(s)

84

1.2

 

14.3