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Table 4 Univariate analysis of prognostic factors on recurrence-free and overall survival

From: Clinical features and prognosis in hepatectomy for colorectal cancer with centrally located liver metastasis

  Number of patient 5-year recurrence-free survival (%) P values 5-year overall survival (%) P values
Overall 159 20.8   34.6  
     39.6 (from diagnosis of primary CRC)
Gender
 Male 89 19.5 0.699 31.5 0.449
 Female 70 26.2   37.7  
Location of the primary tumor(s)
 Transverse colon 18 6.1 0.020 16.7 0.014
 Other area (inclusive of synchronous) 141 24.4   36.4  
Primary tumor staging
 T1, T2, or T3 71 29.0 0.057 42.9 0.017
 T4 88 17.3   27.3  
Regional lymph node metastasis
 Negative 32 41.7 0.002 48.4 0.004
 Positive 127 17.7   30.7  
Primary extrahepatic metastasis
 Negative 141 25.1 0.000 37.9 0.000
 Positive 18 0.0   5.6  
Associated risky presentation(s)
 Negative 138 23.5 0.424 38.0 0.047
 Positive 21 15.1   9.5  
Interval of liver metastasis
 Metachronous 55 38.9 0.001 48.1 0.001
 Synchronous 104 13.8   26.9  
Involved hepatic segment(s)
 Single 59 27.7 0.054 40.7 0.040
 Multiple 100 19.3   30.3  
Metastatic tumor distribution
 Unilobar 114 24.1 0.193 37.2 0.200
 Bilobar 45 18.2   26.7  
Metastatic tumor location
 Peripherally located 135 25.0 0.017 38.8 0.002
 Centrally located 24 8.3   8.3  
Maximal diameter of the largest metastasis
 <5 cm 129 24.5 0.122 38.8 0.008
 ≥5 cm 30 13.9   13.8  
Number of liver metastasis
 Solitary 101 30.0 0.000 40.6 0.001
 Multiple 58 9.0   22.8  
Differentiation of metastatic tumor
 Well differentiated 15 43.1 0.219 (well vs. moderately) 50.0 0.231 (well vs. moderately)
 Moderately differentiated 138 21.1 0.002 (moderately vs. poorly) 34.1 0.000 (moderately vs. poorly)
 Poorly differentiated 6 0.0 0.004 (well vs. poorly) 0.0 0.000 (well vs. poorly)
Mucinous adenocarcinoma
 Yes 13 23.1 0.813 38.5 0.922
 No 146 22.4   33.8  
Neoadjuvant chemotherapy for liver metastasis
 Yes 15 20.0 0.677 35.7 0.477
 No 144 22.8   20.0  
Anatomic resection for liver metastasis
 Yes 32 19.5 0.598 38.8 0.699
 No 127 23.2   33.1  
Resection margin of metastatic tumor
 ≥10 mm 31 40.2 0.013 58.1 0.002
 <10 mm and involved 128 18.2   28.4  
Recurrence after liver resection
 Early recurrence (<4 months) 33    0.0 0.000
 Late recurrence (≥4 months) 89    24.7  
 Involved organ(s) while recurrent
 Confined in liver, lung or both 38 0.0 0.605 26.3 0.027
 Other distant organ(s) 84 1.2   14.3