Clinical features and prognosis in hepatectomy for colorectal cancer with centrally located liver metastasis

Table 3 Management, resection margin, and recurrence status after hepatectomy

	Centrally located	Peripherally located	P values
	( n = 24)	( n = 135)	P values
Neoadjuvant chemotherapy	4 (16.7%)	11 (8.1%)	0.247
Effective (stable, partial/complete response	0 (0.0%)	4 (36.4%)	0.159
Progression	4 (100%)	7 (63.6%)
Anatomic resection^a	7 (29.2%)	25 (18.5%)	0.269
Resection margin (mm)
Involved	10 (41.7%)	20 (14.8%)	0.003
<10 mm	13 (54.2%)	85 (63.0%)
≥10 mm	1 (4.2%)	30 (22.2%)
Recurrence after hepatectomy	22 (91.7%)	100 (74.1%)	0.045
Confined in the liver, lung, or both	7 (31.8%)	31 (31.0%)	1.000
Recurrence in other distant organ(s)	15 (68.2%)	69 (69.0%)
Early recurrence^b	9 (37.5%)	24 (17.8%)	0.032
Repeated hepatectomy	1 (4.2%)	13 (9.6%)	0.696

^aAnatomic resection includes left or right lobectomy, extended left/right lobectomy, or lateral segmetectomy; combination with other hepatectomy methods is excluded; ^bEarly recurrence: less than 4 months after the hepatectomy for the first liver metastasis.