T4 stage and preoperative anemia as prognostic factors for the patients with colon cancer treated with adjuvant FOLFOX chemotherapy

Table 2 Univariate analysis of prognostic factors for DFS and OS

Factor	Classification	p value (DFS)	p value (OS)
Sex	Female
Sex	Male	0.9818	0.8802
Age	<65
Age	≥65	0.5093	0.8196
Cancer location	Right
	Transverse	0.2048	0.0534
	Descending	0.2056	0.5503
	Sigmoid and rectosigmoid	0.7813	0.9634
Lymphovascular invasion	Negative
Lymphovascular invasion	Positive	0.4643	0.2176
Neural invasion	Negative
Neural invasion	Positive	0.3234	0.6679
Histology (differentiation )	Well
	Moderately	0.5575	0.9728
	Poorly	0.9001	0.894
	Signet ring cell	0.1424	0.1516
	Mucinous cell	0.8841	0.8773
WBC	4,000 ~ 10,000 × 10⁶/L
WBC	<4,000 × 10⁶/L	0.8888	0.9328
Hgb	Normal
Hgb	Anemia	0.0019	0.0143
PLT	140 ~ 440 × 10⁹/L
	Thrombocytopenia	0.0444	0.0485
	>440 × 10⁹/L	0.6451	0.7521
Albumin	3.8 ~ 5.3 g/dL
Albumin	<3.8 g/dL	0.3055	0.0298
LDH	129 ~ 240 U/L
LDH	>240 U/L	0.1801	0.2756
Total bilirubin	0.2 ~ 1.0 mg/dL
Total bilirubin	>1.0 mg/dL	0.2247	0.8442
AST	10 ~ 33 U/L
AST	>33 U/L	0.1258	0.4506
ALT	4 ~ 50 U/L
ALT	>50 U/L	0.4121	0.7752
Protein	6.7 ~ 8.3 g/dL
Protein	<6.7 g/dL	0.3451	0.3746
T stage	1
	2
	3
	4	0.0018	0.005
N stage	0
	1	0.2954	0.4345
	2	0.6658	0.1171
Preoperative CEA	≤5 ng/mL
Preoperative CEA	>5 ng/mL	0.4768	0.2144
Postoperative CEA	≤5 ng/mL
Postoperative CEA	>5 ng/mL	0.0585	0.0019
ASA score	1
	2	0.31	0.7768
	3	0.7646	0
Neutropenia	Absent
Neutropenia	Present	0.7597	0.1927
GI Symptom (diarrhea, nausea, anorexia)	Absent
GI Symptom (diarrhea, nausea, anorexia)	Present	0.6714	0.508

ALT, alanine aminotransferase; ASA, American Society of Anesthesiologists; AST, aspartate aminotransferase; CEA, carcinoembryonic antigen; GI symptoms, gastrointestinal symptoms (diarrhea, constipation, anorexia); Hgb, hemoglobin; LDH, lactate dehydrogenase; PLT, platelet; WBC, white blood cell.

ISSN: 1477-7819