Table 1 Further evaluation of the two patients
| Â | Case 1 (14-year-old male) | Case 2 (22-year-old male) |
|---|---|---|
Blood glucose | Normal | Normal |
MRI pituitary examination | No sign of pituitary microadenoma was found in sellar MRI scanning | A low signal shadow with unclear boundary was found at the lower left medial side of the pituitary |
CT adrenal gland examination | No obvious lesion in the bilateral adrenal glands was identified | No obvious lesion in the bilateral adrenal glands was identified |
Examination of Cushing symptoms | Cortisol: 457.9 nmol/L (8 o’clock), 327.2 nmol/L (16 o’clock), 197.3 nmol/L (0 o’clock), corresponding adrenocorticotrophic hormone (ACTH) (8/16/0 o’clock): 18.57 pg/ml; 8.85 pg/ml; <1.0 pg/ml; 24-h urinary free cortisol (UFC): 309.4 nmol/24 h | Cortisol: 353.4 nmol/L(8 o’clock), 218.6 nmol/L (16 o’clock), 70.8 nmol/L (0 o’clock), adrenocorticotrophic hormone (ACTH) (8/16/0 o’clock): 41.80 pg/ml; 31.53 pg/ml; 22.73 pg/ml; 24-h urinary free cortisol (UFC): 308.4 nmol/24 h |