Functional polymorphisms of ATP citrate lyase gene predicts clinical outcome of patients with advanced colorectal cancer

Table 3 Cumulative effect of unfavorable genotypes on overall survival of CRC patients with advanced stage

Group (number of unfavorable genotype) ^a	Death/total	HR (95% CI) ^b	P value	Recurrence/total	HR (95% CI) ^b	P value
Group 1(0)	10/35	Ref.		11/35	Ref.
Group 2(1)	15/39	1.66(0.73–3.78)	0.23	16/39	1.50(0.68–3.30)	0.31
Group 3(2)	84/169	2.24(1.15–4.36)	0.02	93/169	2.33(1.24–4.38)	0.01
P for trend			0.01			0.003

Significant P values (<0.05) are in italics.
Abbreviations: CI, confidence interval; HR, hazard ratio; Ref., reference.
^aUnfavorable genotypes: rs2304497 WW and rs9912300 WW.
^bAdjusted by gender, age, hospital site, tumor position, TNM stage, tumor differentiation, and treatment after surgery where appropriate.

ISSN: 1477-7819