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Table 1 Distribution of patients’ characteristics and prognosis analysis

From: Functional polymorphisms of ATP citrate lyase gene predicts clinical outcome of patients with advanced colorectal cancer

Parameter

All patients, n (%) n = 697

OS

RFS

Death, n (%) n = 205

HR a

95% CI

P value

Recurrence, n (%) n = 240

HR a

95% CI

P value

Gender

         

  Female

314(45.1)

87(42.4)

Ref.

  

100(41.7)

Ref.

  

  Male

383(54.9)

118(57.6)

1.24

0.94–1.64

0.13

140(58.3)

1.29

1.00–1.67

0.06

Age

         

  <60

358(51.4)

99(48.3)

Ref.

  

123(51.3)

Ref.

  

  ≥60

339(48.6)

106(51.7)

1.05

0.80–1.39

0.72

117(48.8)

0.91

0.70–1.17

0.45

Hospital site

         

  Tangdu

454(65.1)

126(61.5)

Ref.

  

140(58.3)

Ref.

  

  Xijing

243(34.9)

79(38.5)

1.01

0.75–1.36

0.93

100(41.7)

1.25

0.95–1.64

0.11

Tumor position

         

  Colon

319(45.8)

93(45.4)

Ref.

  

108(45.0)

Ref.

  

  Rectum

378(54.2)

112(54.6)

1.08

0.82–1.42

0.60

132(55.0)

1.05

0.81–1.36

0.70

TNM stage

         

  I + II

453(65.0)

96(46.8)

Ref.

  

120(50.0)

Ref.

  

  III + IV

244(35.0)

109(53.2)

3.82

2.75–5.33

<0.001

120(50.0)

3.13

2.32–4.23

<0.001

Tumor differentiation

         

  Well

142(20.4)

35(17.1)

Ref.

  

45(18.8)

Ref.

  

  Moderate/poor

555(79.6)

170(82.9)

1.38

0.94–2.03

0.10

195(81.3)

1.26

0.89–1.78

0.19

Treatment after surgery

         

  None

169(24.2)

59(28.8)

Ref.

  

64(26.7)

Ref.

  

  Chemotherapy

528(75.8)

146(71.2)

0.36

0.25–0.52

<0.001

176(73.3)

0.45

0.32–0.63

<0.001

  1. Significant P values (<0.05) are in italics.
  2. Abbreviations: CI, confidence interval; HR, hazard ratio; OS, overall survival; RFS, recurrence free survival; Ref., reference.
  3. aAdjusted by gender, age, hospital site, tumor position, TNM stage, tumor differentiation, and treatment after surgery where appropriate.