Prediction of the preoperative chemoradiotherapy response for rectal cancer by peripheral blood lymphocyte subsets

Tada, Noriko; Kawai, Kazushige; Tsuno, Nelson H; Ishihara, Soichiro; Yamaguchi, Hironori; Sunami, Eiji; Kitayama, Joji; Oba, Koji; Watanabe, Toshiaki

doi:10.1186/s12957-014-0418-0

Table 5 The correlations between the clinicopathological factors and numbers of lymphocyte subsets, pre- and post- CRT

From: Prediction of the preoperative chemoradiotherapy response for rectal cancer by peripheral blood lymphocyte subsets

Gender	Pre-CRT			Post-CRT
	Male	Female	P value	Male	Female	P value
T lymphocytes	1,196 (675 − 2,273)	1,046 (686 − 1,688)	0.325	608 (258 − 1,240)	455 (321 − 1,856)	0.228
Th lymphocytes	667 (329 − 1,489)	587 (383 − 1,180)	0.619	248 (89 − 696)	196 (118 − 692)	0.334
Tc lymphocytes	448 (258 − 855)	374 (200 − 847)	0.083	324 (119 − 671)	238 (137 − 1,144)	0.441
B lymphocytes	140 (31 − 675)	173 (30 − 409)	0.822	40 (1 − 185)	20 (9 − 73)	0.026
Natural killer cells	259 (56 − 966)	236 (135 − 1,020)	0.831	179 (15 − 811)	162 (35 − 497)	0.519
Depth of invasion	Pre-CRT			Post-CRT
	pT0-2	pT3/4	P value	pT0-2	pT3/4	P value
T lymphocytes	1,196 (732 − 2,217)	1,157 (675 − 2,273)	0.489	482 (258 − 1,010)	694 (268 − 1,856)	0.136
Th lymphocytes	683 (329 − 1,496)	513 (361 − 1,364)	0.525	215 (89 − 620)	276 (99 − 696)	0.120
Tc lymphocytes	458 (200 − 847)	394 (270 − 855)	0.658	268 (141 − 495)	348 (119 − 1,144)	0.182
B lymphocytes	172 (73 − 675)	143 (30 − 459)	0.594	31 (1 − 140)	24 (9 − 185)	0.619
Natural killer cells	221 (135 − 966)	268 (56 − 1,020)	0.586	167 (28 − 335)	179 (15 − 811)	0.261
Lymph node metastasis	Pre-CRT			Post-CRT
	Absent	Present	P value	Absent	Present	P value
T lymphocytes 1,135	(675 − 2,273) 1,233	(686 − 1,399)	0.507	494 (268 − 1,856)	628 (258 − 1,240)	0.332
Th lymphocytes	665 (329 − 1,496)	641 (383 − 907)	0.395	217 (99 − 696)	276 (89 − 564)	0.346
Tc lymphocytes	430 (258 − 855)	439 (200 − 752)	0.970	307 (119 − 1144)	316 (167 − 671)	0.324
B lymphocytes	178 (77 − 675)	122 (30 − 459)	0.089	26.5 (9 − 185)	30 (1 − 94)	0.769
Natural killer cells	260 (56 − 929)	232 (124 − 1,020)	0.590	173.5 (15 − 811)	174 (45 − 552)	0.837
Lymphatic invasion	Pre-CRT			Post-CRT
	Absent	Present	P value	Absent	Present	P value
T lymphocytes	1,181 (732 − 2,273)	895 (675 − 2,217)	0.247	494 (258 − 1,856) 694	(366 − 1,240)	0.136
Th lymphocytes	675 (329 − 1,364)	602 (361 − 1,496)	0.491	210 (89 − 696)	276 (226 − 564)	0.100
Tc lymphocytes	453 (258 − 855)	350 (200 − 694)	0.434	268 (137 − 1,144)	348 (119 − 671)	0.206
B lymphocytes	167 (30 − 675)	122 (33 − 185)	0.103	27 (1 − 185)	30 (10 − 70)	0.931
Natural killer cells	232 (56 − 1,020)	495 (135 − 929)	0.199	167 (28 − 811)	201 (15 − 552)	0.283
Venous invasion	Pre-CRT			Post-CRT
	Absent	Present	P value	Absent	Present	P value
T lymphocytes	1,122 (675 − 2,273)	1,181 (686 − 2,217)	0.774	481 (328 − 1,200)	619 (258 − 1,856)	0.227
Th lymphocytes	722 (329 − 1,364)	607 (383 − 1,496)	0.505	224 (146 − 696)	265 (89 − 692)	0.896
Tc lymphocytes	371 (200 − 855)	464 (258 − 847)	0.228	233 (119 − 495)	321 (137 − 1,144)	0.112
B lymphocytes	193 (73 − 409)	137 (30 − 675)	0.370	29 (10 − 185)	25 (1 − 121)	0.520
Natural killer cells	210 (117 − 498)	314 (56 − 1,020)	0.024	132 (15 − 811)	201 (80 − 552)	0.018

Data are expressed as median (range).
Pre-CRT: measured before chemoradiation therapy; post-CRT: measured after chemoradiation therapy.

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